An approach to the patient with late-onset cerebellar ataxia

被引：0
作者：
Brent L Fogel
Susan Perlman
机构：
[1] Department of Neurology,
[2] Ataxia Center,undefined
[3] University of California,undefined
来源：
Nature Clinical Practice Neurology | 2006年 / 2卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background An 83-year-old man presented with hypertension, hyperlipidemia, and a previous basal cell carcinoma, having developed progressive worsening of his balance and difficulty walking at the age of 78 years. He was initially diagnosed with stroke, but MRI revealed only isolated cerebellar atrophy. The patient then underwent multiple evaluations for an underlying paraneoplastic process, all of which were negative, but his symptoms progressed and he remained undiagnosed for several years.
引用
收藏
页码：629 / 635
页数：6
相关论文
共 18 条
[1]  
Maschke M(2005)Clinical feature profile of spinocerebellar ataxia type 1-8 predicts genetically defined subtypes Mov Disord 20 1405-1412
[2]  
Kerber KA(2005)Late-onset pure cerebellar ataxia: Differentiating those with and without identifiable mutations J Neurol Sci 238 41-45
[3]  
Schols L(2004)Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis Lancet Neurol 3 291-304
[4]  
van de Warrenburg BPC(2005)Recent advances in hereditary spinocerebellar ataxias J Neuropathol Exp Neurol 64 171-180
[5]  
Zhuchenko O(1997)Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamate expansions in the α Nat Gen 15 62-69
[6]  
Takahashi H(2004)-voltage-dependent calcium channel J Hum Genet 49 256-264
[7]  
Waters MF(2006)A clinical and genetic study in a large cohort with spinocerebellar ataxia type 6 Nat Gen 38 447-451
[8]  
Perlman S(2004)Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes Neurologist 10 275-289
[9]  
Manto MU(2005)Symptomatic and disease-modifying therapy for the progressive ataxias Cerebellum 4 2-6
[10]  
Mariotti C(2005)The wide spectrum of spinocerebellar ataxias (SCAs) J Neurol 252 511-518
12