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The emerging role of lysine acetylation of non-nuclear proteins
被引:0
作者:
Pierre Close
Catherine Creppe
Magali Gillard
Aurélie Ladang
Jean-Paul Chapelle
Laurent Nguyen
Alain Chariot
机构:
[1] University of Liège,Interdisciplinary Cluster for Applied Genoproteomics (GIGA
[2] University of Liège,R)
[3] University of Liège,GIGA
来源:
Cellular and Molecular Life Sciences
|
2010年
/
67卷
关键词:
Acetylation;
Metabolism;
Migration;
Neurodegenerative disorders;
Cancer;
HDAC;
Sirtuins;
D O I:
暂无
中图分类号:
学科分类号:
摘要:
Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports have also demonstrated that numerous proteins located outside the nucleus are also acetylated and that this modification has profound consequences on their functions. This review describes the latest findings on the substrates acetylated outside the nucleus and on the acetylases and deacetylates that catalyse these modifications. Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders.
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页码:1255 / 1264
页数:9
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