The rules and impact of nonsense-mediated mRNA decay in human cancers

被引：0
|
作者：
Rik G H Lindeboom
Fran Supek
Ben Lehner
机构：
[1] EMBL-CRG Systems Biology Unit,Division of Electronics
[2] Centre for Genomic Regulation (CRG),undefined
[3] Barcelona Institute of Science and Technology,undefined
[4] Universitat Pompeu Fabra (UPF),undefined
[5] Rudjer Boskovic Institute,undefined
[6] Institució Catalana de Recerca i Estudis Avançats (ICREA),undefined
[7] Present address: Department of Molecular Biology,undefined
[8] Radboud Institute for Molecular Life Sciences,undefined
[9] Nijmegen,undefined
[10] the Netherlands.,undefined
来源：
Nature Genetics | 2016年 / 48卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Ben Lehner and colleagues analyze data from matched exomes and transcriptomes from tumors across 27 cancer types to elucidate rules linking premature termination codon location to nonsense-mediated mRNA decay (NMD). They propose a model that explains variability in NMD efficiency and find evidence of positive and negative selection on NMD-initiating mutations in tumors.
引用
收藏
页码：1112 / 1118
页数：6
相关论文
共 50 条
  • [1] The rules and impact of nonsense-mediated mRNA decay in human cancers
    Lindeboom, Rik G. H.
    Supek, Fran
    Lehner, Ben
    NATURE GENETICS, 2016, 48 (10) : 1112 - 1118
  • [2] Nonsense-mediated decay of human HEXA mRNA
    Rajavel, KS
    Neufeld, EF
    MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (16) : 5512 - 5519
  • [3] Nonsense-mediated mRNA decay
    Wen, Jikai
    Brogna, Saverio
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 : 514 - 516
  • [4] Nonsense-mediated mRNA decay
    Maquat, LE
    CURRENT BIOLOGY, 2002, 12 (06) : R196 - R197
  • [5] Nonsense-mediated decay of human LDL receptor mRNA
    Holla, Oystein Lunde
    Kulseth, Mari Ann
    Berge, Knut Erik
    Leren, Trond Paul
    Ranheim, Trine
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2009, 69 (03): : 409 - 417
  • [6] SnapShot: Nonsense-Mediated mRNA Decay
    Durand, Sebastien
    Lykke-Andersen, Jens
    CELL, 2011, 145 (02) : 324 - U2
  • [7] Regulation of nonsense-mediated mRNA decay
    Huang, Lulu
    Wilkinson, Miles F.
    WILEY INTERDISCIPLINARY REVIEWS-RNA, 2012, 3 (06) : 807 - 828
  • [8] Nonsense-mediated mRNA Decay and Cancer
    Popp, Maximilian W.
    Maquat, Lynne E.
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2018, 48 : 44 - 50
  • [9] Nonsense-mediated mRNA decay in mammals
    Maquat, LE
    JOURNAL OF CELL SCIENCE, 2005, 118 (09) : 1773 - 1776
  • [10] Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability
    A’dem Bokhari
    Vincent Jonchere
    Anaïs Lagrange
    Romane Bertrand
    Magali Svrcek
    Laetitia Marisa
    Olivier Buhard
    Malorie Greene
    Anastasia Demidova
    Jieshuang Jia
    Eric Adriaenssens
    Thierry Chassat
    Denis S. Biard
    Jean-François Flejou
    Fabrice Lejeune
    Alex Duval
    Ada Collura
    Oncogenesis, 7
12345