Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

被引：8

作者：

Yang D.-S. ^{[1
]}

Wang S.-M. ^{[1
]}

Peng W.-B. ^{[2
]}

Yang Y.-P. ^{[1
]}

Liu K.-C. ^{[2
]}

Li X.-L. ^{[1
]}

Xiao W.-L. ^{[3
]}

机构：

[1] Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming

[2] Biology Institute of Shandong Academy of Sciences, Jinan

[3] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming

来源：

Natural Products and Bioprospecting | 2015年 / 5卷 / 2期

基金：

中国国家自然科学基金;

关键词：

Cytotoxicity; Macadenanthins A–C; Macaranga adenantha; Prenylated Flavonoids;

D O I：

10.1007/s13659-015-0059-1

中图分类号：

学科分类号：

摘要：

Three new minor prenylated flavonoids, named macadenanthins A–C (1–3), together with three known ones (4–6), were isolated from the twigs of Macaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds 1–3 were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines (MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range of 13.76–22.27 μM. © 2015, The Author(s).

引用

页码：105 / 109

页数：4

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