Targeting LSD1 and FOXA1 in prostate cancer

被引：0
|
作者：
Soleilmane Omarjee
Jason S. Carroll
机构：
[1] University of Cambridge,Cancer Research UK Cambridge Institute
来源：
Nature Genetics | 2020年 / 52卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
FOXA1 is a key pioneer factor in androgen-receptor activity but has been an elusive drug target. A new study shows that inhibition of the associated cofactor LSD1 modifies the methylation state of FOXA1, thus resulting in chromatin dissociation and tumor inhibition, even in models of treatment-resistant prostate cancer.
引用
收藏
页码：1002 / 1003
页数：1
相关论文
共 50 条
  • [1] Targeting LSD1 and FOXA1 in prostate cancer
    Omarjee, Soleilmane
    Carroll, Jason S.
    NATURE GENETICS, 2020, 52 (10) : 1002 - 1003
  • [2] LSD1 inhibitor hinders the demethylation of FOXA1 to inhibit prostate cancer progression
    Zhu, Yongzhen
    Ma, Lijia
    Zhang, Wen
    Wu, Xuelian
    MATERIALS EXPRESS, 2023, 13 (12) : 1990 - 1995
  • [3] LSD1 modulates androgen receptor cistrome in prostate cancer via regulation of FOXA1 chromatin binding
    Gao, Shuai
    Chen, Sujun
    Han, Dong
    Han, Wanting
    Balk, Steven P.
    He, Housheng Hansen
    Cai, Changmeng
    CANCER RESEARCH, 2017, 77
  • [4] FOXA1 in prostate cancer
    Dong, Hui-Yu
    Ding, Lei
    Zhou, Tian-Ren
    Yan, Tao
    Li, Jie
    Liang, Chao
    ASIAN JOURNAL OF ANDROLOGY, 2023, 25 (03) : 287 - 295
  • [5] Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer
    Gao, Shuai
    Chen, Sujun
    Han, Dong
    Wang, Zifeng
    Li, Muqing
    Han, Wanting
    Besschetnova, Anna
    Liu, Mingyu
    Zhou, Feng
    Barrett, David
    Luong, My Phu
    Owiredu, Jude
    Liang, Yi
    Ahmed, Musaddeque
    Petricca, Jessica
    Patalano, Susan
    Macoska, Jill A.
    Corey, Eva
    Chen, Sen
    Balk, Steven P.
    He, Housheng Hansen
    Cai, Changmeng
    NATURE GENETICS, 2020, 52 (10) : 1011 - +
  • [6] Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer
    Shuai Gao
    Sujun Chen
    Dong Han
    Zifeng Wang
    Muqing Li
    Wanting Han
    Anna Besschetnova
    Mingyu Liu
    Feng Zhou
    David Barrett
    My Phu Luong
    Jude Owiredu
    Yi Liang
    Musaddeque Ahmed
    Jessica Petricca
    Susan Patalano
    Jill A. Macoska
    Eva Corey
    Sen Chen
    Steven P. Balk
    Housheng Hansen He
    Changmeng Cai
    Nature Genetics, 2020, 52 : 1011 - 1017
  • [7] FOXA1 chromatin binding is regulated by LSD1-mediated methylation in prostate cancer cells
    Gao, Shuai
    Chen, Sujun
    Han, Dong
    Han, Wanting
    Owiredu, Jude N.
    Balk, Steven P.
    He, Housheng H.
    Cai, Changmeng
    CANCER RESEARCH, 2019, 79 (13)
  • [8] The Sly Oncogene: FOXA1 Mutations in Prostate Cancer
    Shah, Neel
    Brown, Myles
    CANCER CELL, 2019, 36 (02) : 119 - 121
  • [9] FOXA1 regulates alternative splicing in prostate cancer
    Del Giudice, Marco
    Foster, John G.
    Peirone, Serena
    Rissone, Alberto
    Caizzi, Livia
    Gaudino, Federica
    Parlato, Caterina
    Anselmi, Francesca
    Arkell, Rebecca
    Guarrera, Simonetta
    Oliviero, Salvatore
    Basso, Giuseppe
    Rajan, Prabhakar
    Cereda, Matteo
    CELL REPORTS, 2022, 40 (13):
  • [10] Different FOXA1 classes drive prostate cancer
    Stone L.
    Nature Reviews Urology, 2019, 16 (9) : 508 - 508
12345