Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis

被引:0
作者
Huiming Peng
Cao Li
Stephanie Kadow
Brian D. Henry
Jörg Steinmann
Katrin Anne Becker
Andrea Riehle
Natalie Beckmann
Barbara Wilker
Pin-Lan Li
Timothy Pritts
Michael J. Edwards
Yang Zhang
Erich Gulbins
Heike Grassmé
机构
[1] University of Duisburg-Essen,Department of Molecular Biology
[2] University of Duisburg-Essen,Department of Medical Microbiology
[3] University of Cincinnati,Department of Surgery
[4] Virginia Commonwealth University,Department of Pharmacology and Toxicology, Medical College of Virginia
来源
Journal of Molecular Medicine | 2015年 / 93卷
关键词
Acid sphingomyelinase/ceramide system; Lung edema; Superoxide;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:675 / 689
页数:14
相关论文
共 221 条
[11]  
Morrison MA(2003) alpha-toxin: inhibition of endothelial gap formation by adrenomedullin FEBS Lett 534 169-174
[12]  
Nadle J(2001)Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs Biochem Biophys Res Commun 284 1016-1030
[13]  
Petit S(2003)Mechanisms of J Immunol 170 2621-2628
[14]  
Gershman K(2007) induced apoptosis of human endothelial cells Infect Immun 75 5346-5352
[15]  
Ray S(2003)Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis Nat Med 9 322-330
[16]  
Harrison LH(2008)Functional rafts in cell membranes Immunbiology 213 307-314
[17]  
Lynfield R(1997)The transmembranous domain of CD40 determines CD40 partitioning into lipid rafts Cell 91 605-615
[18]  
Dumyati G(1997)Molecular mechanisms of ceramide-mediated CD95 clustering J Exp Med 186 1831-1841
[19]  
Townes JM(2008)Severe impairment in early host defense against J Immunol 181 4247-4254
[20]  
Hocke AC(2012) in mice deficient in acid sphingomyelinase PLoS One 7 e49209-22