Synthesis of neoglycolipids for the development of non-viral gene delivery systems

被引：0
作者：
E. V. Shmendel’
M. A. Maslov
N. G. Morozova
G. A. Serebrennikova
机构：
[1] M. V. Lomonosov Moscow State Academy of Fine Chemical Tehnology,
来源：
Russian Chemical Bulletin | 2010年 / 59卷
关键词：
neoglycolipids; galactose; targeting ligand; 3,4-diethoxycyclobut-3-ene-1,2-dione (diethyl squarate); hepatocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Synthesis of lipid conjugates with galactose as a targeting ligand intended for the development of non-viral systems for the targeted delivery of nucleic acids into hepatocytes is described. 3,4-Diethoxycyclobut-3-ene-1,2-dione (diethyl squarate) was used to bind the galactose moiety to the lipid component.
引用
收藏
页码：2281 / 2289
页数：8
相关论文
共 97 条
[1]  
Li S.(2000)undefined Gene Ther. 7 31-undefined
[2]  
Huang L.(2007)undefined Biotechnol. Mol. Biol. Rev. 2 58-undefined
[3]  
Uddin S. N.(2007)undefined AAPS J. 9 92-undefined
[4]  
Gao X.(2009)undefined Biokhimiya 74 1589-undefined
[5]  
Kim K.-S.(2004)undefined FASEB J. 18 1779-undefined
[6]  
Liu D.(2007)undefined Nat. nanotechnol. 2 751-undefined
[7]  
Tarakhovskii Yu. S.(2006)undefined Usp. Biol. Khim. 46 193-undefined
[8]  
Liu F.(1992)undefined J. Cell. Biochem. Suppl. 16 99-undefined
[9]  
Shollenberger L. M.(2007)undefined Cancer Metast. Rev. 26 141-undefined
[10]  
Huang L.(2007)undefined J. Control. Release 117 281-undefined
12345678910