Synthesis and surface-active properties of fluorinated cyclic PEGyl succinate derivatives

Equimolar reaction of PEG with maleic anhydride in favoring conditions to cyclization is described. The obtained cyclic compounds were submitted to radical addition of 2-F-alkylethanethiol to furnish fluorinated loops. Amphiphilic properties of the latter were investigated by measuring their surface tension and critical micellar concentration CMC. These new amphiphilic compounds may exhibit some interesting interactions with appropriate cations at the surface cells.