A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos

被引：0

作者：

Mika Toya

Masahiro Terasawa

Kayo Nagata

Yumi Iida

Asako Sugimoto

机构：

[1] Laboratory for Developmental Genomics,

[2] RIKEN Center for Developmental Biology,undefined

[3] Laboratory of Developmental Dynamics,undefined

[4] Graduate School of Life Sciences,undefined

[5] Tohoku University,undefined

[6] Present address: Institute for Protein Research,undefined

[7] Osaka University,undefined

[8] Suita,undefined

[9] Osaka 565-0871,undefined

[10] Japan,undefined

来源：

Nature Cell Biology | 2011年 / 13卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos requires the Aurora A kinase. Live-cell imaging and RNAi-based experiments now reveal that the kinase activity of Aurora A is dispensible for this function.

引用

页码：708 / 714

页数：6

共 69 条

[1]

Barr AR(2007)Aurora-A: the maker and breaker of spindle poles J. Cell Sci. 120 2987-2996

[2]

Gergely F(2009)Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins Curr. Opin. Cell Biol. 21 796-805

[3]

Carmena M(2006)Two phases of astral microtubule activity during cytokinesis in Dev. Cell 10 509-520

[4]

Ruchaud S(2002) embryos J. Cell. Biol. 157 591-602

[5]

Earnshaw WC(2001)The kinetically dominant assembly pathway for centrosomal asters in J. Cell Biol. 155 1109-1116

[6]

Motegi F(2001) is γ-tubulin dependent Mol. Biol. Cell. 12 1751-1764

[7]

Velarde NV(2000)Aurora-A kinase is required for centrosome maturation in J. Cell. Sci. 113 3747-3759

[8]

Piano F(2010)Spindle dynamics and the role of γ-tubulin in early Methods Cell. Biol. 97 359-372

[9]

Sugimoto A(1984) embryos J. Cell Biol. 99 47s-54s

[10]

Hannak E(1996)Identification and characterization of Nature 382 420-425

← 1 2 3 4 5 6 7 →