Heterocycles 26: synthesis, characterisation, and anticancer activity of some thiazolic chalcones

被引：0
作者：
Patrice K. Awoussong
Valentin Zaharia
Bathélémy Ngameni
Victor Kuete
Hippolyte N. Ntede
Charles N. Fokunang
Berhanu M. Abegaz
Bonaventure T. Ngadjui
机构：
[1] University of Yaoundé I,Faculty of Science
[2] “Iuliu Hatieganu” University of Medicine and Pharmacy,Faculty of Pharmacy
[3] University of Yaoundé I,Faculty of Medicine and Biomedical Sciences
[4] University of Dschang,Faculty of Science
[5] University of Yaoundé I,National Advanced School of Engineering
[6] Miotoni Lane,African Academy of Sciences
来源：
Medicinal Chemistry Research | 2015年 / 24卷
关键词：
Thiazolic chalcones; Prostate cancer; Hepatocarcinoma; Human monocytic leukemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chalcones and their derivatives have been shown to have potent anticancer activity. A series of aldehydes A1–4 and thiazolic chalcones C1–20 were synthesized and evaluated for their in vitro cytotoxic activity against three human cancer cell lines. In addition, this work led to the synthesis of 12 new thiazolic chalcones using a base-catalyzed Claisen-Schmidt condensation reaction. Compounds C10 and C12 were found to be the most promising biologically active samples with IC50 values below or around 10 µM on both DU-145 and THP-1 cancer cell lines.
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页码：131 / 141
页数：10
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