Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome

被引:0
作者
John A. Kink
Michael A. Bellio
Matthew H. Forsberg
Alexandra Lobo
Anna S. Thickens
Bryson M. Lewis
Irene M. Ong
Aisha Khan
Christian M. Capitini
Peiman Hematti
机构
[1] University of Wisconsin,Department of Medicine, School of Medicine and Public Health
[2] University of Wisconsin Carbone Cancer Center,Interdisciplinary Stem Cell Institute
[3] University of Miami,Department of Pediatrics, School of Medicine and Public Health
[4] Miller School of Medicine,Department of Biostatistics and Medical Informatics, School of Medicine and Public Health
[5] University of Wisconsin,Department of Obstetrics and Gynecology, School of Medicine and Public Health
[6] University of Wisconsin,undefined
[7] University of Wisconsin,undefined
[8] Medical College of Wisconsin,undefined
来源
Stem Cell Research & Therapy | / 15卷
关键词
Extracellular vesicles; Exosomes; Mesenchymal stromal cells; TLR4; Acute radiation syndrome;
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[1]  
Cuende N(2018)Cell, tissue and gene products with marketing authorization in 2018 worldwide Cytotherapy 20 1401-1413
[2]  
Rasko JEJ(2019)Mesenchymal stromal cell therapy: progress in manufacturing and assessments of potency Cytotherapy 21 289-306
[3]  
Koh MBC(2019)Immunomodulation by Mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs Front Immunol 10 1191-2133
[4]  
Dominici M(2015)Biological properties of extracellular vesicles and their physiological functions J Extracell Vesicles 4 27066-662
[5]  
Ikonomou L(2020)Mesenchymal stromal cells and exosomes: progress and challenges Front Cell Dev Biol 8 665-61
[6]  
Robb KP(2020)Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent Int J Mol Sci 21 727-472
[7]  
Fitzgerald JC(2015)Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs Nat Commun 6 8472-592
[8]  
Barry F(2020)Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications Front Cell Dev Biol 8 149-612
[9]  
Viswanathan S(2017)Preservation and storage stability of extracellular vesicles for therapeutic applications AAPS J 20 1-1453
[10]  
Weiss ARR(2019)Macrophages educated with exosomes from primed mesenchymal stem cells treat acute radiation syndrome by promoting hematopoietic recovery Biol Blood Marrow Transpl 25 2124-346