Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes

[1] Hayer M(1999)Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1) Ann Hum Genet 63 473-482

[2] Bonisch H(2007)Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action J Clin Invest 117 1422-1431

[3] Bruss M(2007)Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary care Diabet Med 24 350-358

[4] Shu Y(2011)Does metformin work for everyone? A genome-wide association study for metformin response Curr Diab Rep 11 4679-854

[5] Sheardown SA(2013)The role of pharmacogenetics in drug disposition and response of oral glucose lowering drugs Clin Pharmacokinet 52 833-23

[6] Brown C(2015)Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1 Genome Med 7 1-1793

[7] Cook MN(2015)Association of organic cation transporter 1 with intolerance to metformin in type 2 diabetes: a GoDARTS study Diabetes 64 1786-1240

[8] Girman CJ(2009)Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver Hepatology 50 1227-447

[9] Stein PP(2008)GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation J Chem Theory Comput 4 435-1867

[10] Florez JC(2012)The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program Diabetes Care 35 1864-1977

[1] Hayer M(1999)Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1) Ann Hum Genet 63 473-482

[2] Bonisch H(2007)Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action J Clin Invest 117 1422-1431

[3] Bruss M(2007)Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary care Diabet Med 24 350-358

[4] Shu Y(2011)Does metformin work for everyone? A genome-wide association study for metformin response Curr Diab Rep 11 4679-854

[5] Sheardown SA(2013)The role of pharmacogenetics in drug disposition and response of oral glucose lowering drugs Clin Pharmacokinet 52 833-23

[6] Brown C(2015)Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1 Genome Med 7 1-1793

[7] Cook MN(2015)Association of organic cation transporter 1 with intolerance to metformin in type 2 diabetes: a GoDARTS study Diabetes 64 1786-1240

[8] Girman CJ(2009)Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver Hepatology 50 1227-447

[9] Stein PP(2008)GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation J Chem Theory Comput 4 435-1867

[10] Florez JC(2012)The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program Diabetes Care 35 1864-1977