An Extended Framework of Multiple Testing in Group Sequential Design

被引：0
作者：
Man Jin
Pingye Zhang
机构：
[1] AbbVie Inc,Data and Statistical Sciences
[2] BeiGene,undefined
[3] Ltd.,undefined
来源：
Therapeutic Innovation & Regulatory Science | 2023年 / 57卷
关键词：
Graphical approach; Group sequential trials; Weighted Bonferroni test; Weighted parametric test; Weighted Simes test;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Here, we consider testing multiple hypotheses in group sequential trials. A graphical multiple test procedure was proposed for group sequential trials using weighted Bonferroni test. In this paper, we extend the framework for the graph-based group sequential procedure by applying a modified weighted Simes test. The proposed procedure preserves the familywise error rate. Simulations are conducted to evaluate the performances of the proposed procedure. The proposed procedures are also illustrated with a numerical example.
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页码：662 / 670
页数：8
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