Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation

被引:0
|
作者
Brittany C. Clawson
Emily J. Pickup
Amy Ensing
Laura Geneseo
James Shaver
John Gonzalez-Amoretti
Meiling Zhao
A. Kane York
Femke Roig Kuhn
Kevin Swift
Jessy D. Martinez
Lijing Wang
Sha Jiang
Sara J. Aton
机构
[1] University of Michigan,Department of Molecular, Cellular, and Developmental Biology
[2] Recinto de Gurabo,Universidad Ana G. Mendez
[3] University of Michigan,Neuroscience Graduate Program
[4] VU University,Center for Neurogenomics and Cognitive Research
[5] University of Michigan,Department of Molecular and Integrative Physiology
来源
Nature Communications | / 12卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Learning-activated engram neurons play a critical role in memory recall. An untested hypothesis is that these same neurons play an instructive role in offline memory consolidation. Here we show that a visually-cued fear memory is consolidated during post-conditioning sleep in mice. We then use TRAP (targeted recombination in active populations) to genetically label or optogenetically manipulate primary visual cortex (V1) neurons responsive to the visual cue. Following fear conditioning, mice respond to activation of this visual engram population in a manner similar to visual presentation of fear cues. Cue-responsive neurons are selectively reactivated in V1 during post-conditioning sleep. Mimicking visual engram reactivation optogenetically leads to increased representation of the visual cue in V1. Optogenetic inhibition of the engram population during post-conditioning sleep disrupts consolidation of fear memory. We conclude that selective sleep-associated reactivation of learning-activated sensory populations serves as a necessary instructive mechanism for memory consolidation.
引用
收藏
相关论文
共 50 条
  • [21] The whats and whens of sleep-dependent memory consolidation
    Diekelmann, Susanne
    Wilhelm, Ines
    Born, Jan
    SLEEP MEDICINE REVIEWS, 2009, 13 (05) : 309 - 321
  • [22] Sleep-dependent memory consolidation in patients with schizophrenia
    Krupalija, T.
    Hofer, A.
    Edlinger, M.
    Hinterhuber, H.
    Fleischhacker, W. W.
    Fischer, S.
    JOURNAL OF SLEEP RESEARCH, 2006, 15 : 232 - 233
  • [23] Influence of gender on sleep-dependent memory consolidation
    Spencer, R. M.
    SLEEP, 2008, 31 : A373 - A374
  • [24] The Limited Capacity of Sleep-Dependent Memory Consolidation
    Feld, Gordon B.
    Weis, Patrick P.
    Born, Jan
    FRONTIERS IN PSYCHOLOGY, 2016, 7
  • [25] Dreaming of a Learning Task Is Associated with Enhanced Sleep-Dependent Memory Consolidation
    Wamsley, Erin J.
    Tucker, Matthew
    Payne, Jessica D.
    Benavides, Joseph A.
    Stickgold, Robert
    CURRENT BIOLOGY, 2010, 20 (09) : 850 - 855
  • [26] Sleep-dependent surges in growth hormone do not contribute to sleep-dependent memory consolidation
    Gais, Steffen
    Huellemann, Philipp
    Hallschmid, Manfred
    Born, Jan
    PSYCHONEUROENDOCRINOLOGY, 2006, 31 (06) : 786 - 791
  • [27] SLEEP ENVIRONMENT DETERMINES THE IMPACT OF SLEEP-DEPENDENT MEMORY CONSOLIDATION
    Wang, H.
    Nguyen, N. D.
    Stickgold, R.
    SLEEP, 2012, 35 : A88 - A88
  • [28] Sleep-dependent memory consolidation and its implications for psychiatry
    Monique Goerke
    Notger G. Müller
    Stefan Cohrs
    Journal of Neural Transmission, 2017, 124 : 163 - 178
  • [29] Issues surrounding sleep-dependent memory consolidation and plasticity
    M. P. Walker
    Cellular and Molecular Life Sciences CMLS, 2004, 61 : 3009 - 3015
  • [30] Sleep-dependent memory consolidation and its implications for psychiatry
    Goerke, Monique
    Mueller, Notger G.
    Cohrs, Stefan
    JOURNAL OF NEURAL TRANSMISSION, 2017, 124 : S163 - S178