Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

被引：0
|
作者：
Alexander S. Kulikov
Margarita A. Epishina
Leonid L. Fershtat
Nina N. Makhova
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2018年 / 54卷
关键词：
α-bromo ketones; hydrazinylthiadiazines; ortho esters; thiocarbohydrazide; 7; -1,2,4-triazolo[3,4-; ][1,3,4]thiadiazines; condensation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.
引用
收藏
页码：669 / 672
页数：3
相关论文
共 50 条
  • [1] Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
    Kulikov, Alexander S.
    Epishina, Margarita A.
    Fershtat, Leonid L.
    Makhova, Nina N.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2018, 54 (06) : 669 - 672
  • [2] Synthesis and Antiproliferative Activity of 6-Ferrocenyl-3-substituted 7H-1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazines
    Han, Yin
    Wang, Qin
    Du, Yu-Ping
    Lv, Ming-Hua
    Hui, Xin-Ping
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2009, 56 (01) : 214 - 218
  • [3] A New Approach to the Synthesis of 1,2,4-Triazolo[3,4-b][1,3,4] thiadiazines
    Skryl'nikova, M. A.
    Khramchikhin, A. V.
    Krivchun, M. N.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (06) : 1321 - 1322
  • [4] A new approach to the synthesis of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
    M. A. Skryl’nikova
    A. V. Khramchikhin
    M. N. Krivchun
    Russian Journal of General Chemistry, 2017, 87 : 1321 - 1322
  • [5] Synthesis and spectroscopic properties of bis(3-alkyl/aryl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines
    Li, M
    Wen, LR
    Fu, WJ
    Zhang, YB
    Li, GQ
    Yang, HZ
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2003, 23 (07) : 678 - 681
  • [6] Synthesis and antimicrobial activities of some1,2,4-triazolo [3,4-b] [1,3,4] thiadiazoles and 1,2,4-triazolo [3,4-b] [1,3,4] thiadiazines bearing bistrifluoromethylphenyl moiety
    Bobade, V. D., 1600, Journal of Chemical and Pharmaceutical Research (06):
  • [7] Antimicrobial and antiinflammatory studies on some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles containing quinoxaline
    Wagle, Shivananda
    Adhikari, Airody Vasudeva
    Kumari, Nalilu Suchetha
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (01) : 629 - 641
  • [8] Synthesis of Imidazo[2,1-b][2H-1,3,4]thiadiazines and 1,2,4-Triazolo[3,4-b][2H-1,3,4]thiadiazines
    Knak, Stefanie
    Pfeiffer, Wolf-Diethard
    Dollinger, Horst
    Saghyan, Ashot S.
    Langer, Peter
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 52 (02) : 463 - 467
  • [9] Synthesis and spectroscopic properties of 3-alky/aryl-6-(2′,4′-dichlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines
    Li, M
    Yang, FK
    Wen, LR
    Li, GQ
    Zhang, SS
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2001, 21 (09) : 672 - 675
  • [10] Efficient and Convenient Protocol for the Synthesis of Novel 1,2,4-Triazolo[3,4-b][1,3,4]Thiadiazines
    Foroughifar, Naser
    Mobinikhaledi, Akbar
    Ebrahimi, Sattar
    SYNTHETIC COMMUNICATIONS, 2010, 40 (16) : 2421 - 2428
12345