Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

被引：0
作者：
Jie Liu
Ludovic Renault
Xavier Veaute
Francis Fabre
Henning Stahlberg
Wolf-Dietrich Heyer
机构：
[1] University of California,Department of Microbiology
[2] Davis,Department of Molecular & Cellular Biology
[3] University of California,undefined
[4] Davis,undefined
[5] CEA-DSV-Institut de Radiobiologie Cellulaire et Moléculaire,undefined
[6] UMR217 CNRS/CEA,undefined
[7] Center for Cellular Imaging and Nanoanalytics,undefined
[8] University Basel,undefined
来源：
Nature | 2011年 / 479卷
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摘要：
DNA strand exchange, a process that helps to maintain the integrity of the genome, is promoted in eukaryotes by the Rad51 protein. Eukaryotes also have homologues of Rad51 with functions that are less well defined. Wolf-Dietrich Heyer and colleagues show that in yeast, two of these proteins, Rad55 and Rad57, form a complex that promotes recombination by stabilizing the Rad51 filament against the anti-recombinogenic activity of a helicase, Srs2. These results suggest that the Rad51 filament is a reversible intermediate, the stability of which reflects competing actions of other proteins. This mechanism may have relevance for the human RAD51 paralogues that have important roles in tumour suppression and disease.
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页码：245 / 248
页数：3
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