Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors

[1] Thiebaut F(1987)Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues Proc Natl Acad Sci USA 84 7735-7738

[2] Tsuruo T(1993)Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals Pharmacol Ther 60 289-299

[3] Hamada H(1999)Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine Circulation 99 552-557

[4] Gottesman MM(1997)Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833 J Clin Invest 100 2430-2436

[5] Pastan I(2004)Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance Clin Pharmacol Ther 75 13-33

[6] Willingham MC(1998)The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors J Clin Invest 101 289-294

[7] Borst P(1998)Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein J Pharmacol Exp Ther 286 1439-1445

[8] Schinkel AH(1998)Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters Antimicrob Agents Chemother 42 3157-3162

[9] Smit JJ(1998)HIV-1 protease inhibitors and the MDR1 multidrug transporter J Clin Invest 101 287-288

[10] Wagenaar E(2001)P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance? AIDS 15 1353-1358

[1] Thiebaut F(1987)Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues Proc Natl Acad Sci USA 84 7735-7738

[2] Tsuruo T(1993)Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals Pharmacol Ther 60 289-299

[3] Hamada H(1999)Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine Circulation 99 552-557

[4] Gottesman MM(1997)Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833 J Clin Invest 100 2430-2436

[5] Pastan I(2004)Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance Clin Pharmacol Ther 75 13-33

[6] Willingham MC(1998)The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors J Clin Invest 101 289-294

[7] Borst P(1998)Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein J Pharmacol Exp Ther 286 1439-1445

[8] Schinkel AH(1998)Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters Antimicrob Agents Chemother 42 3157-3162

[9] Smit JJ(1998)HIV-1 protease inhibitors and the MDR1 multidrug transporter J Clin Invest 101 287-288

[10] Wagenaar E(2001)P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance? AIDS 15 1353-1358