Stiff man syndrome and variants [Das Stiff-Man-Syndrom und seine Varianten]

被引:0
作者
Meinck H.-M. [1 ]
机构
[1] Neurologische Universitätsklinik Heidelberg, Im Neuenheimer Feld 400
关键词
Gad autoantibodies; Glyr autoantibodies; Paraneoplastic disorder; Stiff man syndrome; Stiff person syndrome;
D O I
10.1007/s00115-012-3604-8
中图分类号
学科分类号
摘要
Summary: Stiff man syndrome (SMS) and its variants are rare neurological disorders with unusual, often awkward motor and psychological symptoms. Misdiagnoses are frequent and differentiation from psychogenic movement disorder may be difficult. Clinical suspicion can be substantiated by neurophysiological and immunological testing. Autoimmunity against certain proteins of inhibitory synapses appears to be a key feature that links SMS to other autoimmune encephalopathies and endocrinopathies. According to retrospective analyses a front-loaded long-term methylprednisolone treatment appears to be most effective. © 2013 Springer-Verlag Berlin Heidelberg.
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页码:450 / 454
页数:4
相关论文
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