Response to Michiel Alexander de Raaf et al.

[1] Jiang B(2016)Marked strain-specific differences in the SU5416 rat model of severe pulmonary arterial hypertension Am J Respir Cell Mol Biol 54 461-8

[2] Deng Y(2012)New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis Pulm Circ 2 434-42

[3] Suen C(2014)The Sugen 5416/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up Pulm Circ 4 619-29

[4] Taha M(2014)Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats Am J Physiol Heart Circ Physiol 306 H243-250

[5] Chaudhary KR(2012)New mechanisms of pulmonary arterial hypertension: role of Ca(2)(+) signaling Am J Physiol Heart Circ Physiol 302 H1546-62

[6] Courtman DW(1998)Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation J Biol Chem 273 30336-43

[7] Nicolls MR(2001)Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery Am J Pathol 158 1145-60

[8] Mizuno S(2014)The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox Am J Respir Cell Mol Biol 51 474-84

[9] Taraseviciene-Stewart L(2004)Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways Am J Pathol 165 1071-85

[10] Farkas L(2013)Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology J Am Coll Cardiol 62 D22-33

[1] Jiang B(2016)Marked strain-specific differences in the SU5416 rat model of severe pulmonary arterial hypertension Am J Respir Cell Mol Biol 54 461-8

[2] Deng Y(2012)New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis Pulm Circ 2 434-42

[3] Suen C(2014)The Sugen 5416/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up Pulm Circ 4 619-29

[4] Taha M(2014)Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats Am J Physiol Heart Circ Physiol 306 H243-250

[5] Chaudhary KR(2012)New mechanisms of pulmonary arterial hypertension: role of Ca(2)(+) signaling Am J Physiol Heart Circ Physiol 302 H1546-62

[6] Courtman DW(1998)Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation J Biol Chem 273 30336-43

[7] Nicolls MR(2001)Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery Am J Pathol 158 1145-60

[8] Mizuno S(2014)The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox Am J Respir Cell Mol Biol 51 474-84

[9] Taraseviciene-Stewart L(2004)Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways Am J Pathol 165 1071-85

[10] Farkas L(2013)Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology J Am Coll Cardiol 62 D22-33