Molecular classification of cutaneous malignant melanoma by gene expression profiling

被引：0
作者：
M. Bittner
P. Meltzer
Y. Chen
Y. Jiang
E. Seftor
M. Hendrix
M. Radmacher
R. Simon
Z. Yakhini
A. Ben-Dor
N. Sampas
E. Dougherty
E. Wang
F. Marincola
C. Gooden
J. Lueders
A. Glatfelter
P. Pollock
J. Carpten
E. Gillanders
D. Leja
K. Dietrich
C. Beaudry
M. Berens
D. Alberts
V. Sondak
N. Hayward
J. Trent
机构：
[1] Cancer Genetics Branch,Department of Surgery
[2] National Human Genome Research Institute,undefined
[3] NIH,undefined
[4] Department of Anatomy and Cell Biology University of Iowa Cancer Center,undefined
[5] National Cancer Institute,undefined
[6] DCTDC,undefined
[7] NIH,undefined
[8] Chemical and Biological Systems Department Agilent Laboratories,undefined
[9] Computer Science and Engineering Department University of Washington,undefined
[10] Department of Electrical Engineering Texas A & M University,undefined
[11] National Cancer Institute,undefined
[12] Surgery Branch,undefined
[13] NIH,undefined
[14] Queensland Institute of Medical Research ,undefined
[15] Neuro-Oncology Laboratory,undefined
[16] Barrow Neurological Institute,undefined
[17] Arizona Cancer Center,undefined
[18] University of Arizona,undefined
[19] University of Michigan,undefined
来源：
Nature | 2000年 / 406卷
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摘要：
The most common human cancers are malignant neoplasms of the skin1,2. Incidence of cutaneous melanoma is rising especially steeply, with minimal progress in non-surgical treatment of advanced disease3,4. Despite significant effort to identify independent predictors of melanoma outcome, no accepted histopathological, molecular or immunohistochemical marker defines subsets of this neoplasm2,3. Accordingly, though melanoma is thought to present with different ‘taxonomic’ forms, these are considered part of a continuous spectrum rather than discrete entities2. Here we report the discovery of a subset of melanomas identified by mathematical analysis of gene expression in a series of samples. Remarkably, many genes underlying the classification of this subset are differentially regulated in invasive melanomas that form primitive tubular networks in vitro, a feature of some highly aggressive metastatic melanomas5. Global transcript analysis can identify unrecognized subtypes of cutaneous melanoma and predict experimentally verifiable phenotypic characteristics that may be of importance to disease progression.
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页码：536 / 540
页数：4
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  • [1] Hall HI(1999)Update on the incidence and mortality from melanoma in the United States. J. Am. Acad. Dermatol. 40 35- 42
  • [2] Miller DR(1999)Classification of cutaneous malignant melanoma: a reassessment of histopathologic criteria for the distinction of different types. Cancer 86 288- 299
  • [3] Rogers J D(1998)Pathologic parameters in the diagnosis and prognosis of primary cutaneous melanoma. Hematol. Oncol. Clin. North Am. 12 717-735
  • [4] Bewerse B(1999)Recent advances in melanoma staging and therapy. Ann. Surg. Oncol. 6 467-475,
  • [5] Weyers W(1999)Vascular channel formation by human melanoma cells Am. J. Pathol. 155 739-752
  • [6] Euler M(1996) and Nature Genet. 14 457- 460
  • [7] Diaz-Cascajo C(1998): vasculogenic mimicry. Cancer Res. 58 5009- 5013
  • [8] Schill WB(1999)Use of a cDNA microarray to analyse gene expression patterns in human cancer. Proc. Natl Acad. Sci. USA 96 9212-9217
  • [9] Bonczkowitz M(1999)Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. Science 286 531-537,
  • [10] Byers HR(2000)Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Nature 403 503-511
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