Molecular Modeling of the Post-Diffusion Stage of Surface Bio-Tissue Layers Immersion Optical Clearing

被引：4

作者：

Dvoretsky K.N. ^{[1
]}

Berezin K.V. ^{[2
,3
]}

Chernavina M.L. ^{[2
]}

Likhter A.M. ^{[3
]}

Shagautdinova I.T. ^{[3
]}

Antonova E.M. ^{[3
]}

Grechukhina O.N. ^{[6
]}

Tuchin V.V. ^{[2
,4
,5
]}

机构：

[1] Saratov State Medical University, Saratov

[2] National Research Saratov State University, Saratov

[3] Astrakhan State University, Astrakhan

[4] Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov

[5] National Research Tomsk State University, Tomsk

[6] Caspian Institute for Marine and River Transport, Astrakhan

来源：

Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques | 2018年 / 12卷 / 5期

关键词：

collagen; glycerin; immersion optical clearing of biological tissues; molecular dynamics; molecular modeling;

D O I：

10.1134/S1027451018050233

中图分类号：

学科分类号：

摘要：

The interaction of an immersion agent such as glycerin with collagen mimetic peptide ((GPH)9)3 and a fragment of microfibril 5((GPH)12)3 is studied by the classical molecular dynamics method using GROMACS software. The change in the geometric parameters of collagen α-chains at various concentrations of an aqueous solution of glycerin is analyzed. It is shown that these changes nonlinearly depend on the concentration and have a maximum that fit well with experimental data on the efficiency of the optical clearing of a human skin. A reason for the decrease in the efficiency of skin optical clearing at high immersion-agent concentrations is proposed. The molecular mechanism of the immersion optical clearing of biological tissues is discussed. © 2018, Pleiades Publishing, Ltd.

引用

页码：961 / 967

页数：6

共 30 条

[1]

Hirshburg J.M., PhD Thesis, (2009)

[2]

Tuchin V.V., Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, (2009)

[3]

Tuchin V.V., Optical Clearing of Tissues and Blood, (2006)

[4]

Zhu D., Larin K.V., Luo Q., Tuchin V.V., Laser Photonics Rev., 7, 5, (2013)

[5]

Genina E.A., Bashkatov A.N., Sinichkin Y.P., Yanina I.Y., Tuchin V.V., J. Biomed. Photonics Eng., 1, 1, (2015)

[6]

Genina E.A., Bashkatov A.N., Kochubey V.I., Tuchin V.V., Opt. Spectrosc., 98, 3, (2005)

[7]

Genina E.A., Bashkatov A.N., Sinichkin Y.P., Tuchin V.V., Kvantovaya Elektron., 36, 12, (2006)

[8]

Genina E.A., Bashkatov A.N., Tuchin V.V., Adv. Opt. Technol., 2008, (2008)

[9]

Bashkatov A.N., Genina E.A., Tuchin V.V., Altshuler G.B., Laser Phys., 19, 6, (2009)

[10]

Wen X., Tuchin V.V., Luo Q., Zhu D., Phys. Med. Biol., 54, 22, (2009)

← 1 2 3 →