Determination of methylparaben, propylparaben, clotrimazole and its degradation products in topical cream by RP-HPLC

被引：0
作者：
P. Solich
R. Hájková
M. Pospíšilová
J. Šícha
机构：
[1] Charles University,Department of Analytical Chemistry, Faculty of Pharmacy
[2] Herbacos-Bofarma Ltd,Bochemie Group
来源：
Chromatographia | 2002年 / 56卷
关键词：
Column liquid chromatography; Pharmaceuticals; Degradation products; Methylparaben; Propylparaben; Clotrimazol;
D O I：
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中图分类号：
学科分类号：
摘要：
Reversed-phase, high-performance liquid chromatographic (RP-HPLC) methods with UV detection were developed and validated for determination of compounds in a topical cream. The first method describes determination of the active component clotrimazole and two preservatives present in the cream; methylparaben and propylparaben. The second method describes determination of two degradation products of clotrimazole, imidazole and (2-chlorophenyl) diphenylmethanol, in a topical cream after long-term stability tests.
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页码：S181 / S184
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