Genetics of atrial fibrillation—an update of recent findings

被引：0
作者：
Aarthi Manoharan
Ravikumar Sambandam
Vishnu Bhat Ballambattu
机构：
[1] Aarupadai Veedu Medical College and Hospital,Multi
来源：
Molecular Biology Reports | 2022年 / 49卷
关键词：
Genome-wide association studies; Whole-exome sequencing; Whole-genome sequencing; Atrial fibrillation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong genetic predisposition. This review highlights the recent findings on the genetics of AF from genome-wide association studies (GWAS) and high-throughput sequencing studies. The consensus from GWAS implies that AF is both polygenic and pleiotropic in nature. With the advent of whole-genome sequencing and whole-exome sequencing, rare variants associated with AF pathogenesis have been identified. The recent studies have contributed towards better understanding of AF pathogenesis.
引用
收藏
页码：8121 / 8129
页数：8
相关论文
共 230 条
[71]  
Lin J(1997)Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors EMBO J 12 1-1379
[72]  
Lin S(2018)Association between Titin loss-of-function variants and early-onset atrial fibrillation JAMA 6 1371-undefined
[73]  
Choy PC(2018)Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation Nat Commun undefined undefined-undefined
[74]  
Ellinor PT(2015)Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation J Med Genet undefined undefined-undefined
[75]  
Lunetta KL(2016)A novel nonsense mutation in LMNA gene identified by exome sequencing in an atrial fibrillation family Eur J Med Genet undefined undefined-undefined
[76]  
Glazer NL(2010)Genetic and ultrastructural studies in dilated cardiomyopathy patients: a large deletion in the lamin A/C gene is associated with cardiomyocyte nuclear envelope disruption Basic Res Cardiol undefined undefined-undefined
[77]  
Orr N(2016)Whole exome sequencing in atrial fibrillation PLoS Genet undefined undefined-undefined
[78]  
Arnaout R(2021)Early-onset atrial fibrillation and the prevalence of rare variants in cardiomyopathy and arrhythmia genes JAMA Cardiol undefined undefined-undefined
[79]  
Gula LJ(undefined)undefined undefined undefined undefined-undefined
[80]  
Latham SL(undefined)undefined undefined undefined undefined-undefined
3456789101112