Genetics of atrial fibrillation—an update of recent findings

被引：0
作者：
Aarthi Manoharan
Ravikumar Sambandam
Vishnu Bhat Ballambattu
机构：
[1] Aarupadai Veedu Medical College and Hospital,Multi
来源：
Molecular Biology Reports | 2022年 / 49卷
关键词：
Genome-wide association studies; Whole-exome sequencing; Whole-genome sequencing; Atrial fibrillation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong genetic predisposition. This review highlights the recent findings on the genetics of AF from genome-wide association studies (GWAS) and high-throughput sequencing studies. The consensus from GWAS implies that AF is both polygenic and pleiotropic in nature. With the advent of whole-genome sequencing and whole-exome sequencing, rare variants associated with AF pathogenesis have been identified. The recent studies have contributed towards better understanding of AF pathogenesis.
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页码：8121 / 8129
页数：8
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