Radiation-induced osteosarcoma after Gamma Knife surgery for vestibular schwannoma: a case report and literature review

被引：8

作者：

Se, Young-Bem ^{[1
]}

Kim, Dong Gyu ^{[1
]}

Park, Sung-Hye ^{[2
]}

Chung, Hyun-Tai ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Neurosurg, 101 Daehak Ro, Seoul 110744, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Pathol, Seoul Natl Univ Hosp, Seoul, South Korea

来源：

ACTA NEUROCHIRURGICA | 2017年 / 159卷 / 02期

关键词：

Stereotactic radiosurgery; Gamma Knife radiosurgery; Vestibular schwannoma; Radiation-induced sarcoma; Osteosarcoma; MALIGNANT-TRANSFORMATION; STEREOTACTIC RADIOSURGERY; POSTIRRADIATION SARCOMA; POSTRADIATION SARCOMA; TUMOR; HEAD; RADIOTHERAPY; RISK;

D O I：

10.1007/s00701-016-3031-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present a rare case of radiation-induced osteosarcoma following Gamma Knife(A (R)) surgery (GKS) for a vestibular schwannoma (VS). A 49-year-old female with sporadic VS underwent GKS. Serial follow-up imaging showed that the tumor size decreased. Six years after GKS, magnetic resonance imaging demonstrated regrowth of the tumor. The tumor was removed via the retrosigmoid approach. Interestingly, the final pathology report confirmed osteosarcoma arising in schwannoma with direct transition (osteosarcoma component: 90 %, schwannoma component: 10 %). The osteosarcoma was considered to be a radiation-induced malignancy. The possibility of this rare complication should be explained to the patient before GKS, and the patient should be screened periodically after GKS.

引用

页码：385 / 391

页数：7

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