Multimodal treatment of perianal fistulas in Crohn’s disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial

被引：0
作者：
E. Joline de Groof
Christianne J. Buskens
Cyriel Y. Ponsioen
Marcel G. W. Dijkgraaf
Geert R. A. M. D’Haens
Nidhi Srivastava
Gijs J. D. van Acker
Jeroen M. Jansen
Michael F. Gerhards
Gerard Dijkstra
Johan F. M. Lange
Ben J. M. Witteman
Philip M. Kruyt
Apollo Pronk
Sebastiaan A. C. van Tuyl
Alexander Bodelier
Rogier M. P. H. Crolla
Rachel L. West
Wietske W. Vrijland
Esther C. J. Consten
Menno A. Brink
Jurriaan B. Tuynman
Nanne K. H. de Boer
Stephanie O. Breukink
Marieke J. Pierik
Bas Oldenburg
Andrea E. van der Meulen
Bert A. Bonsing
Antonino Spinelli
Silvio Danese
Matteo Sacchi
Janindra Warusavitarne
Ailsa Hart
Nuha A. Yassin
Rory P. Kennelly
Garret J. Cullen
Desmond C. Winter
A. Barney Hawthorne
Jared Torkington
Willem A. Bemelman
机构：
[1] Academic Medical Center,Department of Surgery
[2] Academic Medical Center,Department of Gastroenterology and Hepatology
[3] Clinical Research Unit,Department of Gastroenterology and Hepatology
[4] Academic Medical Center,Department of Surgery
[5] Medical Center Haaglanden,Department of Gastroenterology and Hepatology
[6] Medical Center Haaglanden,Department of Surgery
[7] Onze Lieve Vrouwe Gasthuis,Department of Gastroenterology and Hepatology
[8] Onze Lieve Vrouwe Gasthuis,Department of Surgery
[9] University Medical Center Groningen,Department of Gastroenterology and Hepatology
[10] University Medical Center Groningen,Department of Surgery
[11] Hospital Gelderse Vallei,Department of Surgery
[12] Hospital Gelderse Vallei,Department of Gastroenterology and Hepatology
[13] Diakonessenhuis Utrecht,Department of Gastroenterology and Hepatology
[14] Diakonessenhuis Utrecht,Department of Surgery
[15] Amphia Hospital,Department of Gastroenterology and Hepatology
[16] Amphia Hospital,Department of Surgery
[17] St Franciscus Gasthuis,Department of Surgery
[18] St Franciscus Gasthuis,Department of Gastroenterology and Hepatology
[19] Meander Medical Center,Department of Surgery
[20] Meander Medical Center,Department of Gastroenterology and Hepatology
[21] VU Medical Center,Department of Surgery
[22] VU Medical Center,Department of Gastroenterology and Hepatology
[23] Maastricht University Medical Center,Department of Gastroenterology and Hepatology
[24] Maastricht University Medical Center,Department of Gastroenterology and Hepatology
[25] University Medical Center Utrecht,Department of Surgery
[26] Leiden University Medical Center,Department of Surgery
[27] Leiden University Medical Center,Department of Gastroenterology and Hepatology
[28] Humanitas Hospital,Department of Surgery
[29] Humanitas Hospital,Department of Gastroenterology and Hepatology
[30] St Mark’s Hospital,Department of Surgery
[31] St Mark’s Hospital,Department of Gastroenterology and Hepatology
[32] St Vincent’s Healthcare Group,Department of Gastroenterology and Hepatology
[33] St Vincent’s Healthcare Group,Department of Surgery
[34] Spire Cardiff Hospital,undefined
[35] Spire Cardiff Hospital,undefined
来源：
Trials | / 16卷
关键词：
Crohn’s disease; Perianal fistula; Seton; Anti-TNF; Advancement plasty; Quality of life; Cost-effectiveness;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 131 条
[1]  
Hellers G(1980)Occurrence and outcome after primary treatment of anal fistulae in Crohn’s disease Gut. 21 525-7
[2]  
Bergstrand O(2011)Incidence and clinical outcomes of intersphincteric abscesses diagnosed by anal ultrasonography in patients with Crohn’s disease Inflamm Bowel Dis. 17 2102-8
[3]  
Ewerth S(2004)Long-term outcome following loose-seton technique for external sphincter preservation in complex anal fistula Br J Surg. 91 476-80
[4]  
Holmstrom B(2010)Clinical advantages of combined seton placement and infliximab maintenance therapy for perianal fistulizing Crohn’s disease: when and how were the seton drains removed? Hepatogastroenterology. 57 3-7
[5]  
Vigano C(2010)Endorectal advancement flap for cryptoglandular or Crohn’s fistula-in-ano Dis Colon Rectum. 53 486-95
[6]  
Losco A(2006)Infliximab in fistulizing Crohn’s disease Gastroenterol Clin North Am. 35 795-820
[7]  
Caprioli F(1999)Infliximab for the treatment of fistulas in patients with Crohn’s disease N Engl J Med. 340 1398-405
[8]  
Basilisco G(2010)The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn’s disease who failed prior infliximab therapy Aliment Pharmacol Ther. 32 1228-39
[9]  
Buchanan GN(2001)Clinical use of infliximab in Crohn’s disease: the Edinburgh experience Aliment Pharmacol Ther. 15 1639-46
[10]  
Owen HA(2002)Infliximab in treatment of Crohn’s disease: the Milan experience Dig Liver Dis. 34 411-8
12345678910