Systemic mastocytosis presenting as osteoporosis—a case report

被引:0
作者
R. Mathew
V. Dhillon
P. Shepherd
机构
[1] Western General Hospital,Department of Rheumatology
[2] Western General Hospital,Department of Haematology
来源
Clinical Rheumatology | 2009年 / 28卷
关键词
Osteoporosis; Systemic mastocytosis;
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摘要
Mastocytosis is a clonal disorder of the mast cell and its precursor cells, and is characterised by proliferation and accumulation of mast cells within various organs, most commonly the skin. Systemic mastocytosis is a rare but well-recognised cause of secondary osteoporosis, accounting for about 1.25% of cases. The pathophysiological mechanism is probably multifactorial, including increased osteoclastic activity, and a direct effect of mast cell mediators like histamine, heparin, tryptase and cytokines. Here, we report the case of a middle-aged male patient with osteoporotic vertebral fractures as a rare presenting manifestation of systemic mastocytosis. In summary, systemic mastocytosis, although rare, should be considered as a cause in patients with idiopathic osteoporosis.
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页码:865 / 866
页数:1
相关论文
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