Treatment of systemic lupus erythematosus patients with the BAFF antagonist “peptibody” blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials

被引:0
作者
William Stohl
Joan T. Merrill
R. John Looney
Jill Buyon
Daniel J. Wallace
Michael H. Weisman
Ellen M. Ginzler
Blaire Cooke
Donna Holloway
Arunan Kaliyaperumal
Kameswara Rao Kuchimanchi
Tsui Chern Cheah
Erik Rasmussen
John Ferbas
Shelley S. Belouski
Wayne Tsuji
Debra J. Zack
机构
[1] Los Angeles County and University of Southern California Medical Center and University of Southern California Keck School of Medicine, Division of Rheumatology
[2] Oklahoma Medical Research Foundation,undefined
[3] University of Rochester,undefined
[4] Hospital for Joint Disease,undefined
[5] Cedars-Sinai Medical Center,undefined
[6] SUNY Downstate Medical Center,undefined
[7] Amgen Inc.,undefined
[8] Formerly of Amgen,undefined
[9] Los Angeles County + University of Southern California Medical Center and Keck School of Medicine of the University of Southern California,undefined
来源
Arthritis Research & Therapy | / 17卷
关键词
Systemic Lupus Erythematosus; Systemic Lupus Erythematosus Patient; Belimumab; Median Fluorescence Intensity; Systemic Lupus Erythematosus Disease Activity;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 253 条
[1]  
Thompson J(2000)BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population J Exp Med. 192 129-135
[2]  
Schneider P(2000)Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response J Exp Med. 192 953-964
[3]  
Kalled S(2000)BAFF mediates survival of peripheral immature B lymphocytes J Exp Med. 192 1453-1466
[4]  
Wang L(2001)TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease impaired B cell maturation in mice lacking BLyS Immunity. 15 289-302
[5]  
Lefevre E(2001)An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway Science. 293 2111-2114
[6]  
Cachero T(1999)Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations J Exp Med. 190 1697-1710
[7]  
Do R(2000)Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice PNAS. 97 3370-3375
[8]  
Hatada E(2000)TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease Nature. 404 995-999
[9]  
Lee H(2005)BAFF overexpression and accelerated glomerular disease in mice with incomplete genetic predisposition to systemic lupus erythematosus Arthritis Rheum. 52 2080-2091
[10]  
Tourigny M(2007)BAFF and MyD88 signals promote a lupus-like disease independent of T cells J Exp Med. 204 1959-1971