Synthesis of fluorine-containing betulin esters

被引：0
作者：
T. S. Khlebnikova
Yu. A. Piven′
V. A. Nikolaevich
A. V. Baranovskii
F. A. Lakhvich
Nguen Van Tuen
机构：
[1] Institute of Bioorganic Chemistry,
[2] National Academy of Sciences of Belarus,undefined
[3] Chemistry Institute of the Viet Nam Academy of Sciences and Technology,undefined
来源：
Chemistry of Natural Compounds | 2012年 / 47卷
关键词：
betulin; acylation; fluorine-containing betulin esters;
D O I：
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摘要：
28-O-Fluoroacylbetulins were synthesized via acylation of betulin by fluorocarboxylic (perfluorobutyric, perfluorooctanoic, 3-fluorobenzoic, perfluorobenzoic) acid chlorides in CHCl3 in the presence of Py. 3,28-Di-O-fluoroacylbetulins were prepared by treatment of betulin with fluorocarboxylic (trifluoroacetic, pentafluoropropionic) acid anhydrides in Py in the presence of 4-dimethylaminopyridine. 3,28-Di-O- (3-fluorobenzoyl)betulin was obtained from acylation of betulin by 3-fluorobenzoic acid in CH2Cl2 in the presence of N,N′-dicyclohexylcarbodiimide and 4-dimethylaminopyridine whereas acylation by perfluorobutyric acid under the same conditions gave 28-O-perfluorobutanoylbetulin.
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页码：921 / 924
页数：3
相关论文
共 44 条
[1]  
Tolstikova TG(2006)undefined Bioorg. Khim. 32 42-undefined
[2]  
Sorokina IV(2006)undefined Eur. J. Pharm. Sci. 29 1-undefined
[3]  
Tolstikov GA(2005)undefined Khim. Interesakh Ustoich. Razvit. 13 1-undefined
[4]  
Tolstikov AG(2006)undefined Bioorg. Khim. 32 291-undefined
[5]  
Flekhter OB(2004)undefined ChemBioChem 5 571-undefined
[6]  
Sami A(2008)undefined J. Med. Chem. 51 4359-undefined
[7]  
Taru M(2010)undefined J. Fluorine Chem. 131 1071-undefined
[8]  
Salme K(2010)undefined Usp. Khim. 79 929-undefined
[9]  
Jari Y-K(2010)undefined Zh. Org. Khim. 46 1485-undefined
[10]  
Tolstikov GA(2002)undefined Bioorg. Khim. 28 543-undefined
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