Genetic sources of individual differences in the cerebellum

被引：9

作者：

Airey D.C. ^{[1
,2
]}

Lu L. ^{[1
]}

Shou S. ^{[1
]}

Williams R.W. ^{[1
]}

机构：

[1] Department of Anatomy and Neurobiology, University of Tennessee, Memphis, TN

[2] Department of Pharmacology, Vanderbilt University, 8144 Medical Research Building Three, Nashville

来源：

The Cerebellum | 2002年 / 1卷 / 4期

基金：

美国国家科学基金会;

关键词：

Cerebellar size and form; Complete trait analysis; Foliation; Gene microarray; Individual differences; QTL mapping; Quantitative trait locus;

D O I：

10.1080/147342202320883542

中图分类号：

学科分类号：

摘要：

The highly regular anatomy of the cerebellum that results from myriad genetic, environmental, and stochastic events during pre- and postnatal development is nonetheless quantitatively very different among individuals. Understanding the sources of these individual differences represents an immense challenge to those interested in the cerebellum. Here we highlight the use of new methods to dissect individual differences to their genetic sources by reviewing quantitative trait locus mapping efforts in the mouse model system. We further suggest and illustrate how to combine these methods with other modern genetic techniques to accelerate our understanding. Finally, we embed these methods in a hypothetical line of cerebellar research to illustrate the vast potential of combining complex trait analysis with a systems neuroscience perspective. © 2002 Martin Dunitz Ltd.

引用

页码：233 / 240

页数：7

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