Synchronous Parotid (Mammary Analog) Secretory Carcinoma and Acinic Cell Carcinoma: Report of a Case

被引：0
作者：
C. Mossinelli
C. Pigni
F. Sovardi
A. Occhini
L. Preda
M. Benazzo
P. Morbini
F. Pagella
机构：
[1] University of Pavia and Fondazione IRCCS Policlinico San Matteo,Department of Otolaryngology
[2] University of Pavia,Department of Clinical, Surgical, Diagnostic and Paediatric Sciences
[3] University of Pavia and Fondazione IRCCS Policlinico San Matteo,Department of Molecular Medicine
来源：
Head and Neck Pathology | 2019年 / 13卷
关键词：
MASC; Salivary gland tumor; Cystic carcinoma; Parotid; Acinic cell carcinoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mammary analogue secretory carcinoma (MASC) is a recently described low-grade salivary gland malignancy with histologic, immunohistochemical and molecular similarities to secretory carcinoma of the breast, including a specific t(12;15)(p13;q25) resulting in an ETV6–NTRK3 gene fusion. Ultrasound and magnetic resonance imaging frequently document a macrocystic structure. The main differential diagnosis of secretory carcinoma is with low grade acinic cell carcinoma (AciCC). The two can be differentiated with immunohistochemical stains for S100, mammaglobin, carbonic anhydrase VI and DOG-1; the identification of the specific translocation can help to characterize non-typical cases. We report a unique case of synchronous MASC and AciCC presenting in a parotid gland and discuss the implications of the correct identification of the two tumors.
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页码：686 / 691
页数：5
相关论文
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[1]  
Skálová A(2010)Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity Am J Surg Pathol 11 1-2
[2]  
Vanecek T(2017)Update from the 4th edition of the World Health Organization classification of head and neck tumours: preface Head Neck Pathol 61 387-394
[3]  
Sima R(2012)Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands Histopathology 7 35-39
[4]  
Seethala R(2013)Unmasking MASC: bringing to light the unique morphologic, immunohistochemical and genetic features of the newly recognized mammary analogue secretory carcinoma of salivary glands Head Neck Pathol 140 997-1001
[5]  
Chiosea S(2016)Mammary analogue secretory carcinoma Arch Pathol Lab Med 7 30-36
[6]  
Griffith C(2013)Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity Head Neck Pathol 40 3-13
[7]  
Assaad A(2016)Mammary analogue secretory carcinoma of salivary glands Am J Surg Pathol 42 234-246
[8]  
Seethala R(2018)Molecular profiling of mammary analog secretory carcinoma revealed a subset of tumors harboring a novel ETV6-RET translocation Am J Surg Pathol 37 454-471
[9]  
Bishop J(2016)Parotid gland lesions: multiparametric ultrasound and MRI features Ultraschall Med 43 495-509
[10]  
Stevens T(2015)Diagnostic problems of salivary gland tumors Diagn Cytopathol 44 519-525
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