Mice without telomerase: what can they teach us about human cancer?

被引：0

作者：

Steven E. Artandi

Ronald A. DePinho

机构：

[1] Dana-Farber Cancer Institute,Department of Adult Oncology

[2] Harvard Medical School,Departments of Genetics and Medicine

来源：

Nature Medicine | 2000年 / 6卷

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D O I：

暂无

中图分类号：

学科分类号：

摘要：

Unicellular organisms, human cells and mice have provided insights into the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer.

引用

页码：852 / 855

页数：3

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