Distribution of Latent Herpes Simplex Virus Type-1 and Varicella Zoster Virus DNA in Human Trigeminal Ganglia

被引：0
作者：
Randall J. Cohrs
James J. Laguardia
Donald Gilden
机构：
[1] University of Colorado Health Sciences Center,Departments of Neurology
[2] University of Colorado Health Sciences Center,Departments of Microbiology
[3] Southern Illinois University School of Medicine,Department of Neurology
来源：
Virus Genes | 2005年 / 31卷
关键词：
distribution; human; herpes simplex virus-1; PCR; trigeminal ganglia; varicella zoster virus;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Trigeminal ganglia removed at autopsy from immunocompetent individuals without cutaneous signs of herpesvirus infection were fixed, cut into 5-μm sections, and screened at 100-μm intervals (20 adjacent sections) by PCR for latent herpes simplex type 1(HSV-1) and varicella zoster virus (VZV) DNA. Sections that contained >5 neurons with nuclei stained by hematoxylin/eosin revealed HSV-1 DNA in most samples and VZV DNA in approximately 50% of samples. HSV-1 and VZV DNA were distributed throughout each latently infected ganglion.
引用
收藏
页码：223 / 227
页数：4
相关论文
共 81 条
[1]  
Clarke P.(1995)undefined J Virol 69 8151-8154
[2]  
Beer T.(1986)undefined J Virol 57 446-455
[3]  
Cohrs R.(2003)undefined Proc Natl Acad Sci USA 100 7871-7876
[4]  
Gilden D.H.(2000)undefined J Viral 74 11464-11471
[5]  
Efstathiou S.(1998)undefined Proc Natl Acad Sci USA 95 4658-4662
[6]  
Minson A.C.(1999)undefined J Virol 73 8571-8577
[7]  
Field H.J.(1987)undefined Science 235 1056-1059
[8]  
Anderson J.R.(2002)undefined J Virol Methods 104 21-32
[9]  
Wilily P.(2003)undefined J Virol 77 6979-6987
[10]  
Jackson S.A.(2000)undefined Neurol Res 22 565-566
123456789