The synthesis of ω-(2-aryl-1,3-dioxolan-2-yl)alkyl purine derivatives and their activity towards HIV reverse transcriptase

被引：0
作者：
V. V. Komissarov
V. T. Valuev-Elliston
O. N. Ivanova
S. N. Kochetkov
A. M. Kritzyn
机构：
[1] Russian Academy of Sciences,Engelhardt Institute of Molecular Biology
来源：
Russian Journal of Bioorganic Chemistry | 2015年 / 41卷
关键词：
alkylation; HIV reverse transcriptase; non-competitive inhibitors; polymethylene purine derivatives; purines;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Novel derivatives of 6-substituted purines were synthesized by alkylation of 6-substituted purines with various 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. Their inhibitory properties toward HIV reverse transcriptase were studied. The structure-activity relationship within the synthesized compounds was found.
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页码：37 / 45
页数：8
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