Valproic acid suppresses interleukin-1β-induced microsomal prostaglandin E2 Synthase-1 expression in chondrocytes

被引:0
|
作者
N Zayed
N Chabane
J Martel-Pelletier
J P Pelletier
N Duval
H Fahmi
机构
[1] Notre-Dame Hospital,Osteoarthritis Research Unit, Research Centre of the University of Montreal Hospital Center (CR
[2] and Dept. of Medicine,CHUM)
[3] University of Montreal,undefined
关键词
PGE2; Valproic Acid; Histone Deacetylase; Transient Transfection; Chromatin Immunoprecipitation;
D O I
10.1186/1479-5876-8-S1-P60
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Valproic Acid Suppresses Interleukin-1β-induced Microsomal Prostaglandin E2 Synthase-1 Expression in Chondrocytes Through Upregulation of NAB1
    Zayed, Nadia
    El Mansouri, Fatima Ezzahra
    Chabane, Nadir
    Kapoor, Mohit
    Martel-Pelletier, Johanne
    Benderdour, Mohamed
    Pelletier, Jean-Pierre
    Duval, Nicolas
    Fahmi, Hassan
    JOURNAL OF RHEUMATOLOGY, 2011, 38 (03) : 492 - 502
  • [2] Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2
    Annaleise V Sampey
    Seetha Monrad
    Leslie J Crofford
    Arthritis Research & Therapy, 7
  • [3] Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1
    Wu, Tom Y. H.
    Juteau, Helene
    Ducharme, Yves
    Friesen, Richard W.
    Guiral, Sebastien
    Dufresne, Lynn
    Poirier, Hugo
    Salem, Myriam
    Riendeau, Denis
    Mancini, Joseph
    Brideau, Christine
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) : 6978 - 6982
  • [4] Cyclooxygenase-2, Not Microsomal Prostaglandin E Synthase-1, Is the Mechanism for Interleukin-1β-induced Prostaglandin E2 Production and Inhibition of Insulin Secretion in Pancreatic Islets
    Parazzoli, Susan
    Harmon, Jamie S.
    Vallerie, Sara N.
    Zhang, Tao
    Zhou, Huarong
    Robertson, R. Paul
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (38) : 32246 - 32253
  • [5] Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes
    H Afif
    X Li
    J Martel-Pelletier
    J-P Pelletier
    H Fahmi
    Arthritis Res Ther, 6 (Suppl 3):
  • [6] Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia
    Kim, Beomsue
    Lee, Jee-Hyung
    Yang, Myung-Soon
    Jou, Ilo
    Joe, Eun-Hye
    JOURNAL OF NEUROSCIENCE RESEARCH, 2008, 86 (06) : 1353 - 1360
  • [7] Microsomal prostaglandin E2 synthase-1 and its inhibitors: Molecular mechanisms and therapeutic significance
    Zhang, Yan-Yu
    Yao, Yun-Da
    Luo, Jin-Fang
    Liu, Zhong-Qiu
    Huang, Yu-Ming
    Wu, Fei-Chi
    Sun, Qin-Hua
    Liu, Jian-Xin
    Zhou, Hua
    PHARMACOLOGICAL RESEARCH, 2022, 175
  • [8] Microsomal Prostaglandin E2 Synthase-1 as a New Macromolecular Drug Target in the Prevention of Inflammation and Cancer
    Bulbul, Bahadir
    Kucukguzel, Ilkay
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2019, 19 (10) : 1205 - 1222
  • [9] Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages
    Ninomiya, Yuichi
    Yasuda, Toshimichi
    Kawamoto, Masashi
    Yuge, Osafumi
    Okazaki, Yasushi
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2007, 103 (01) : 44 - 50
  • [10] Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo
    Kats, Anna
    Bage, Tove
    Georgsson, Pierre
    Jonsson, Jorgen
    Quezada, Hernan Concha
    Gustafsson, Anders
    Jansson, Leif
    Lindberg, Claes
    Nasstrom, Karin
    Yucel-Lindberg, Tulay
    FASEB JOURNAL, 2013, 27 (06) : 2328 - 2341