Racial and ethnic disparities in a real-world precision oncology data registry

被引：0
作者：
Alexander T. M. Cheung
Elina L. Palapattu
Isabella R. Pompa
Christopher M. Aldrighetti
Andrzej Niemierko
Henning Willers
Franklin Huang
Neha Vapiwala
Eliezer Van Allen
Sophia C. Kamran
机构：
[1] NYU Grossman School of Medicine,Department of Radiation Oncology, Massachusetts General Hospital
[2] Broad Institute of Harvard and MIT,Division of Hematology/Oncology, Department of Medicine
[3] Dana-Farber Cancer Institute,Department of Radiation Oncology
[4] Harvard Medical School,undefined
[5] University of California,undefined
[6] San Francisco,undefined
[7] Hospital of the University of Pennsylvania,undefined
[8] Perelman School of Medicine,undefined
来源：
npj Precision Oncology | / 7卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Biorepositories enable precision oncology research by sharing clinically annotated genomic data, but it remains unknown whether these data registries reflect the true distribution of cancers in racial and ethnic minorities. Our analysis of Project Genomics Evidence Neoplasia Information Exchange (GENIE), a real-world cancer data registry designed to accelerate precision oncology discovery, indicates that minorities do not have sufficient representation, which may impact the validity of studies directly comparing mutational profiles between racial/ethnic groups and limit generalizability of biomarker discoveries to all populations.
引用
收藏
相关论文
共 29 条
  • [1] Giaquinto AN(2022)Cancer statistics for African American/Black People 2022 CA Cancer J. Clin. 72 202-229
  • [2] Spratt DE(2016)Racial/ethnic disparities in genomic sequencing JAMA Oncol. 2 1070-1074
  • [3] Consortium APG(2017)AACR Project GENIE: powering precision medicine through an international consortium Cancer Discov. 7 818-831
  • [4] Mahal BA(2020)Racial differences in genomic profiling of prostate cancer N. Engl. J. Med. 383 1083-1085
  • [5] Goel N(2022)Racial differences in genomic profiles of breast cancer JAMA Netw. open 5 e220573-e220573
  • [6] Nassar AH(2021)Distribution of KRASG12C somatic mutations across race, sex, and cancer type N. Engl. J. Med. 384 185-187
  • [7] Adib E(2021)Tumor mutations across racial groups in a real-world data registry JCO Precis. Oncol. 5 1654-1658
  • [8] Kwiatkowski DJ(2021)Race and genetic alterations in prostate cancer JCO Precis. Oncol. 5 PO.21.00324-102
  • [9] Kamran SC(2021)The invisibility of Asian Americans in COVID-19 data, reporting, and relief Am. J. Bioeth. 21 100-252
  • [10] Schumacher FR(2022)Getting genetic ancestry right for science and society Science 376 250-165
123