Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry?

[1] Richardson SJ(2013)Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas Diabetologia 229 719-728

[2] Leete P(2013)Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins J Pathol 3 373-382

[3] Dhayal S(2002)Target cell defense prevents the development of diabetes after viral infection Nat Immunol 174 1171-1177

[4] Hansson SF(2005)RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection J Immunol 60 884-889

[5] Korsgren S(2011)RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes Diabetes 329 381-394

[6] Ponten F(2004)Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection Virology 27 965-970

[7] Korsgren O(2011)Pathological changes in the pancreas of fulminant type 1 diabetes and slowly progressive insulin-dependent diabetes mellitus (SPIDDM): innate immunity in fulminant type 1 diabetes and SPIDDM Diabetes Metab Res Rev 86 3271-3280

[8] Flodstrom M(2005)Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection J Gen Virol 51 1796-1802

[9] Maday A(2008)Analysis of pancreas tissue in a child positive for islet cell antibodies Diabetologia 104 5115-5120

[10] Balakrishna D(2007)Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients Proc Natl Acad Sci U S A 56 185-193

[1] Richardson SJ(2013)Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas Diabetologia 229 719-728

[2] Leete P(2013)Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins J Pathol 3 373-382

[3] Dhayal S(2002)Target cell defense prevents the development of diabetes after viral infection Nat Immunol 174 1171-1177

[4] Hansson SF(2005)RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection J Immunol 60 884-889

[5] Korsgren S(2011)RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes Diabetes 329 381-394

[6] Ponten F(2004)Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection Virology 27 965-970

[7] Korsgren O(2011)Pathological changes in the pancreas of fulminant type 1 diabetes and slowly progressive insulin-dependent diabetes mellitus (SPIDDM): innate immunity in fulminant type 1 diabetes and SPIDDM Diabetes Metab Res Rev 86 3271-3280

[8] Flodstrom M(2005)Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection J Gen Virol 51 1796-1802

[9] Maday A(2008)Analysis of pancreas tissue in a child positive for islet cell antibodies Diabetologia 104 5115-5120

[10] Balakrishna D(2007)Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients Proc Natl Acad Sci U S A 56 185-193