Vitamin D Supplementation in Overweight/obese Asian Indian Women with Prediabetes Reduces Glycemic Measures and Truncal Subcutaneous Fat: A 78 Weeks Randomized Placebo-Controlled Trial (PREVENT-WIN Trial)

被引:46
作者
Bhatt, Surya Prakash [1 ,2 ,3 ,5 ]
Misra, Anoop [1 ,2 ,5 ]
Pandey, Ravindra Mohan [4 ]
Upadhyay, Ashish Datt [4 ]
Gulati, Seema [1 ,2 ]
Singh, Namrata [1 ,2 ]
机构
[1] Diabet Fdn India, Safdarjung Dev Area, New Delhi 110016, India
[2] Natl Diabet Obes & Cholesterol Fdn N DOC, Safdarjung Dev Area, New Delhi 110016, India
[3] All India Inst Med Sci, Dept Pulm Med & Sleep Disorders, New Delhi 110029, India
[4] All India Inst Med Sci, Biostat, New Delhi 110029, India
[5] Fortis C DOC Ctr Excellence Diabet Metab Dis & En, B-16 Chirag Enclave, New Delhi, India
关键词
INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; ABDOMINAL OBESITY; DOUBLE-BLIND; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; D-DEFICIENT; INDIVIDUALS; CALCIUM; RISK;
D O I
10.1038/s41598-019-56904-y
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Vitamin D deficiency may contribute to etiology of type 2 diabetes in Asian Indians. The objectives of this study was to evaluate effect of vitamin D supplementation on glycemic profile and body composition in prediabetic and vitamin D deficient overweight/obese Asian Indian women. In this open-label randomized placebo-controlled trial (78 weeks duration), 121 females (aged 20-60 years) with prediabetes and vitamin D deficiency were randomly allocated in intervention (n, 61) and placebo (n, 60) groups. The primary outcome variables were fasting blood glucose (FBG), 2-h blood glucose post OGTT (2-h BG), hemoglobin A1c (HbA1C), and reversal to normoglycemia. In Intention-to-treat analysis, at the end of intervention, we observed significant decrease in FBG [-5.0 (-12.6-2.4), p = 0.04], 2-h blood glucose post OGTT [-11(-49.3-26.9), p = 0.02], hemoglobin A1c [-0.41 (5.89, 6.55), p = 0.05] and increase in 25(OH) D [7.5 (-6.0-20.9), p = 0.002] levels in intervention as compared to the placebo group. Changes in glycemic category based on FBG were as follows; intervention group: normal FBG, 58.6%; impaired fasting glucose (IFG), 39%; and type 2 diabetes mellitus (T2DM), 2.4%; placebo group: normal FBG, 48.8%; IFG, 46.3%; and T2DM, 4.9%. Changes in category of 2-hour glucose post OGTT after intervention were as follows; intervention group: normal glucose tolerance (NGT) 51.2% and prediabetes, 48.8%; placebo group: NGT, 43.9%; prediabetes, 53.7% and T2DM, 2.4%. After intervention, subscapular skinfold (visit Ist compared to visit IIIrd) and suprailiac skinfold (visit IInd compared to visit IIIrd) were significantly lower in intervention group vs. control group. In conclusion, we observed significant reduction in FBG, 2-hour glucose post OGTT, HbA1c, and truncal subcutaneous fat and reversal to normoglycemia in overweight/obese prediabetic vitamin D deficient Asian Indian women after 78 weeks of vitamin D supplementation.
引用
收藏
页数:13
相关论文
共 47 条
[1]   Low Circulating 25-Hydroxyvitamin D Concentrations Are Associated with Defects in Insulin Action and Insulin Secretion in Persons with Prediabetes [J].
Abbasi, Fahim ;
Blasey, Christine ;
Feldman, David ;
Caulfield, Michael P. ;
Hantash, Feras M. ;
Reaven, Gerald M. .
JOURNAL OF NUTRITION, 2015, 145 (04) :714-719
[2]   Classification and Diagnosis of Diabetes [J].
不详 .
DIABETES CARE, 2015, 38 :S8-S16
[3]   EFFECT OF THE HIGH-DOSE VITAMIN D REPLETION ON GLYCEMIC CONTROL IN AFRICAN-AMERICAN MALES WITH PREDIABETES AND HYPOVITAMINOSIS D [J].
Barengolts, Elena ;
Manickam, Buvana ;
Eisenberg, Yuval ;
Akbar, Arfana ;
Kukreja, Subhash ;
Ciubotaru, Irina .
ENDOCRINE PRACTICE, 2015, 21 (06) :604-612
[4]   The Effects of Vitamin D on Skeletal Muscle Strength, Muscle Mass, and Muscle Power: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [J].
Beaudart, Charlotte ;
Buckinx, Fanny ;
Rabenda, Veronique ;
Gillain, Sophie ;
Cavalier, Etienne ;
Slomian, Justine ;
Petermans, Jean ;
Reginster, Jean-Yves ;
Bruyere, Olivier .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (11) :4336-4345
[5]   Lower vitamin D levels are associated with higher blood glucose levels in Asian Indian women with pre-diabetes: a population-based cross-sectional study in North India [J].
Bhatt, Surya Prakash ;
Misra, Anoop ;
Gulati, Seema ;
Singh, Naamrata ;
Pandey, Ravindra Mohan .
BMJ OPEN DIABETES RESEARCH & CARE, 2018, 6 (01)
[6]   Vitamin D Insufficiency Is Associated with Abdominal Obesity in Urban Asian Indians Without Diabetes in North India [J].
Bhatt, Surya Prakash ;
Misra, Anoop ;
Sharma, Mukti ;
Guleria, Randeep ;
Pandey, Ravindra Mohan ;
Luthra, Kalpana ;
Vikram, Naval Kishore .
DIABETES TECHNOLOGY & THERAPEUTICS, 2014, 16 (06) :392-397
[7]   Independent associations of low 25 hydroxy vitamin D and high parathyroid hormonal levels with nonalcoholic fatty liver disease in Asian Indians residing in north India [J].
Bhatt, Surya Prakash ;
Nigam, Priyanka ;
Misra, Anoop ;
Guleria, Randeep ;
Pasha, M. A. Qadar .
ATHEROSCLEROSIS, 2013, 230 (01) :157-163
[8]   Association of the Myostatin Gene with Obesity, Abdominal Obesity and Low Lean Body Mass and in Non-Diabetic Asian Indians in North India [J].
Bhatt, Surya Prakash ;
Nigam, Priyanka ;
Misra, Anoop ;
Guleria, Randeep ;
Luthra, Kalpana ;
Jain, S. K. ;
Pasha, M. A. Qadar .
PLOS ONE, 2012, 7 (08)
[9]   RAPID NORMALIZATION STIMULATION BY 1,25-DIHYDROXYVITAMIN-D3 OF INSULIN-SECRETION AND GLUCOSE-TOLERANCE IN THE VITAMIN D-DEFICIENT RAT [J].
CADE, C ;
NORMAN, AW .
ENDOCRINOLOGY, 1987, 120 (04) :1490-1497
[10]   Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials [J].
Chandler, Paulette D. ;
Wang, Lu ;
Zhang, Xi ;
Sesso, Howard D. ;
Moorthy, Manickavasagar V. ;
Obi, Obiageli ;
Lewis, Joshua ;
Prince, Richard L. ;
Danik, Jacqueline S. ;
Manson, Joann E. ;
LeBoff, Meryl S. ;
Song, Yiqing .
NUTRITION REVIEWS, 2015, 73 (09) :577-593