Reinfections and Trypanosoma cruzi strains can determine the prognosis of the chronic chagasic cardiopathy in mice

被引:0
作者
Juan M. Bustamante
Mónica Novarese
Héctor W. Rivarola
María S. Lo Presti
Alicia R. Fernández
Julio E. Enders
Ricardo Fretes
Patricia A. Paglini-Oliva
机构
[1] Universidad Nacional de Córdoba,Cátedra de Física Biomédica, Facultad de Ciencias Médicas
[2] Universidad Nacional de Córdoba,Cátedra de Histología, Embriología y Genética II, Facultad de Ciencias Médicas
来源
Parasitology Research | 2007年 / 100卷
关键词
Trypanosoma Cruzi; Cardiac Damage; Cardiac Lesion; Parasite Strain; Electrocardiographic Abnormality;
D O I
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中图分类号
学科分类号
摘要
Chronic Chagas’ disease represents the result of the interaction between the host and the parasite, producing different clinical features: from a mild disease to a severe heart failure. In the present investigation, we analyzed whether Trypanosoma cruzi strain and/or reinfections in the acute stage, determine changes in the chronic phase (135 days postinfection, d.p.i) that could explain the diverse evolution of cardiac lesions. After infection of albino Swiss mice (n = 170) with 50 blood trypomastigote of the T. cruzi, strain Tulahuen (n = 80) and the isolate SGO-Z12 (n = 90), respectively, and reinfections at 10 and 20 d.p.i. Parasitemia, survival, electrocardiography, affinity and density of cardiac β-receptors and histopathology of the heart were studied. Parasitemias in reinfected mice were significantly higher than those in single-infected mice. Survival of SGO-Z12-infected group was significantly higher than the other groups (p < 0.01). All Tulahuen-reinfected mice and 55–67% of the infected and SGO-Z12-reinfected groups presented some electrocardiographic abnormality (p < 0.01). Hearts from single-infected mice presented fibber disorganization and necrosis; reinfected groups also exhibited fibber fragmentation and a diminished affinity and a higher beta-adrenergic receptors’ density than the other groups (p < 0.05). Therefore, parasite strain and reinfections determine different cardiac damage, and either (or both) of these factors are involved in the severity of the clinical picture and the prognosis of the chronic cardiac disease.
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页码:1407 / 1410
页数:3
相关论文
共 48 条
[1]  
Bustamante JM(2002) reinfections in mice determine the severity of cardiac damage Int J Parasitol 32 889-896
[2]  
Rivarola HW(2003) reinfections provoke synergistic effect and cardiac β-adrenergic receptors’ dysfunction in the acute phase of experimental Chagas’ disease Exp Parasitol 103 136-142
[3]  
Fernández AR(2004)Entomological aspects of Chagas’ disease transmission in the domestic habitat, Argentina Rev Saúde Pública 38 216-222
[4]  
Enders JE(2002)Pathogenesis of chronic Chagas’ heart disease: parasite persistence and autoimmune responses versus cardiac remodelling and neurohormonal activation Int J Parasitol 32 107-109
[5]  
Fretes R(2003)Pathophysiology of the heart in Chagas’ disease: current status and new developments Cardiovasc Res 60 96-107
[6]  
Bustamante JM(2004): genetic structure of population and relevance of genetic variability to the pathogenesis of Chagas’ disease Mem Inst Oswaldo Cruz 99 1-12
[7]  
Rivarola HW(1996)Characterization of Am J Trop Med Hyg 55 625-628
[8]  
Fernández AR(1990) population by zymodemes: correlation with clinical picture WHO 68 737746-635
[9]  
Enders JE(2006)Probability of transmission of Chagas disease by Trop Med Int Health 11 628-undefined
[10]  
Fretes R(undefined) (Hemiptera, Reduviidae) in an endemic area of Santigo del Estero, Argentina undefined undefined undefined-undefined