Therapeutic Potential of HO-1 in Autoimmune Diseases

被引：0
作者：
Bao-Zhu Li
Biao Guo
Hai-Yan Zhang
Juan Liu
Sha-Sha Tao
Hai-Feng Pan
Dong-Qing Ye
机构：
[1] Anhui Medical University,Department of Epidemiology and Biostatistics, School of Public Health
[2] Anhui Medical University,Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis
[3] Anhui Medical University,School of Health Service Management
[4] Anhui Medical University,Department of Hygiene Analysis and Detection, School of Public Health
来源：
Inflammation | 2014年 / 37卷
关键词：
heme oxygenase-1; carbon monoxide; autoimmune diseases; anti-inflammation; immunomodulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Heme oxygenase-1 (HO-1), the inducible isoform of heme oxygenase (HO), has raised a lot of concerns in recent years due to its multiple functions. HO-1 was found to be a pivotal cytoprotective, antioxidant, anti-apoptotic, immunosuppressive, as well as anti-inflammatory molecule. Recent studies have clarified its significant functions in many diseases with substantial findings. In autoimmune diseases, HO-1 may have promising therapeutic potential. Here, we briefly reviewed recent advances in this field, aiming at hopefully exploring the potential therapeutic roles of HO-1, and design HO-1-based strategies for the treatment of autoimmune diseases.
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页码：1779 / 1788
页数：9
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