Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)

被引：0
作者：
Guanggai Xia
Hongcheng Wang
Ziliang Song
Qingcai Meng
Xiuyan Huang
Xinyu Huang
机构：
[1] Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Department of general surgery
[2] Fudan University Shanghai Cancer Center,Department of Pancreatic Surgery, Pancreatic Cancer Institute
来源：
Journal of Experimental & Clinical Cancer Research | / 36卷
关键词：
Pancreatic cancer; Gemcitabine; Gambogic acid; RRM2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 33 条
  • [21] Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone
    Liu, XY
    Zhou, BS
    Xue, LJ
    Qiu, WH
    Shih, J
    Zheng, S
    Yen, Y
    [J]. BIOCHEMICAL PHARMACOLOGY, 2004, 67 (08) : 1499 - 1511
  • [22] Ribonucleotide reductase M2 subunit silencing suppresses tumorigenesis in pancreatic cancer via inactivation of PI3K/AKT/mTOR pathway
    Shan, Jinlan
    Wang, Zhen
    Mo, Qiuping
    Long, Jingpei
    Fan, Yangfan
    Cheng, Lu
    Zhang, Tao
    Liu, Xiyong
    Wang, Xiaochen
    [J]. PANCREATOLOGY, 2022, 22 (03) : 401 - 413
  • [23] Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine
    Souglakos, J.
    Boukovinas, I.
    Taron, M.
    Mendez, P.
    Mavroudis, D.
    Tripaki, M.
    Hatzidaki, D.
    Koutsopoulos, A.
    Stathopoulos, E.
    Georgoulias, V.
    Rosell, R.
    [J]. BRITISH JOURNAL OF CANCER, 2008, 98 (10) : 1710 - 1715
  • [24] Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine
    J Souglakos
    I Boukovinas
    M Taron
    P Mendez
    D Mavroudis
    M Tripaki
    D Hatzidaki
    A Koutsopoulos
    E Stathopoulos
    V Georgoulias
    R Rosell
    [J]. British Journal of Cancer, 2008, 98 : 1710 - 1715
  • [25] Excision repair cross-complementing gene-1, ribonucleotide reductase subunit M1, ribonucleotide reductase subunit M2, and human equilibrative nucleoside transporter-1 expression and prognostic value in biliary tract malignancy
    Fisher, Sarah B.
    Fisher, Kevin E.
    Patel, Sameer H.
    Lim, Matthew G.
    Kooby, David A.
    El-Rayes, Bassel F.
    Staley, Charles A., III
    Adsay, N. Volkan
    Farris, Alton B., III
    Maithel, Shishir K.
    [J]. CANCER, 2013, 119 (02) : 454 - 462
  • [26] Small Interfering RNA (siRNA)-Mediated Silencing of the M2 Subunit of Ribonucleotide Reductase A Novel Therapeutic Strategy in Ovarian Cancer
    Zhang, Meng
    Wang, Jing
    Yao, RuYong
    Wang, LiMing
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2013, 23 (04) : 659 - 666
  • [27] The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 (RRM1) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)
    Lee, Jae Jin
    Maeng, Chi Hoon
    Baek, Seon Kyung
    Kim, Gou Young
    Yoo, Jee-Hong
    Choi, Cheon Woong
    Kim, Yee Hyung
    Kwak, Young-Tae
    Kim, Dae-Hyun
    Lee, Young Kyung
    Kim, Jung Bo
    Kim, Si-Young
    [J]. LUNG CANCER, 2010, 70 (02) : 205 - 210
  • [28] pERK1/2 silencing sensitizes pancreatic cancer BXPC-3 cell to gemcitabine-induced apoptosis via regulating Bax and Bcl-2 expression
    Wang, Min
    Lu, Xingjiao
    Dong, Xueguang
    Hao, Fengyun
    Liu, Zimin
    Ni, Guangzhen
    Chen, Dong
    [J]. WORLD JOURNAL OF SURGICAL ONCOLOGY, 2015, 13
  • [29] pERK1/2 silencing sensitizes pancreatic cancer BXPC-3 cell to gemcitabine-induced apoptosis via regulating Bax and Bcl-2 expression
    Min Wang
    Xingjiao Lu
    Xueguang Dong
    Fengyun Hao
    Zimin Liu
    Guangzhen Ni
    Dong Chen
    [J]. World Journal of Surgical Oncology, 13
  • [30] Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages
    Qiaofei Liu
    Yuan Li
    Zheyu Niu
    Yi Zong
    Mengyi Wang
    Lutian Yao
    Zhaohui Lu
    Quan Liao
    Yupei Zhao
    [J]. Journal of Experimental & Clinical Cancer Research, 35
1234