Anhedonia in combat veterans with penetrating head injury

被引：0
作者：
Jeffrey D. Lewis
Frank Krueger
Vanessa Raymont
Jeffrey Solomon
Kristine M. Knutson
Aron K. Barbey
Joshua C. Poore
Eric M. Wassermann
Jordan Grafman
机构：
[1] National Institute of Neurological Disorders and Stroke,Beckman Institute for Advanced Science and Technology
[2] West London Mental Health Trust and Imperial College,undefined
[3] Expert Image Analysis,undefined
[4] University of Illinois at Urbana-Champaign,undefined
[5] Draper Laboratories,undefined
[6] Rehabilitation Institute of Chicago,undefined
[7] Northwestern University,undefined
来源：
Brain Imaging and Behavior | 2015年 / 9卷
关键词：
Anhedonia; Traumatic brain injury; Reward; Motivational anhedonia; Depression; Ventrolateral prefrontal cortex;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.
引用
收藏
页码：456 / 460
页数：4
相关论文
共 78 条
  • [1] Beck AT(1996)Comparison of beck depression inventories -IA and -II in psychiatric outpatients Journal of Personality Assessment 67 588-597
  • [2] Steer RA(2011)In the trenches of real-world self-control: neural correlates of breaking the link between craving and smoking Psychological Science 22 498-506
  • [3] Ball R(2014)Training-induced changes in inhibitory control network activity Journal of Neuroscience 34 149-157
  • [4] Ranieri W(1995)The development of a clinician-administered PTSD scale Journal of Traumatic Stress 8 75-90
  • [5] Berkman ET(2014)Dysphoria and anhedonia as risk factors for disability or death in older persons: implications for the assessment of geriatric depression The American Journal of Geriatric Psychiatry 22 606-613
  • [6] Falk EB(2005)The neural correlates of anhedonia in major depressive disorder Biological Psychiatry 58 843-853
  • [7] Lieberman MD(2015)Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia Neuroscience and Biobehavioral Reviews 51 189-204
  • [8] Berkman ET(2009)Anhedonia in schizophrenia and major depression: state or trait? Annals Genetic Psychiatry 8 22-327
  • [9] Kahn LE(2005)Toward an objective characterization of an anhedonic phenotype: a signal-detection approach Biological Psychiatry 57 319-222
  • [10] Merchant JS(2007)Apathy syndrome after traumatic brain injury compared with deficits in schizophrenia Psychosomatics 48 217-558
12345678