Synthesis and biological activity of n-acyl-4-phenyl-1,2-epoxy-2,3,3a,4,5,9b-hexahydro-1h-cyclopenta[c]quinolines

被引：0
作者：
G. F. Krainova
L. V. Anikina
Yu. B. Vikharev
V. A. Glushkov
机构：
来源：
Pharmaceutical Chemistry Journal | 2012年 / 45卷
关键词：
Quinoline; Povarov reaction; epoxides; neurotropic activity;
D O I：
暂无
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学科分类号：
摘要：
Oxidation of substituted N-acyl-4-phenyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolines led to the corresponding 1,2-epoxides and 1,2-diols. The synthesized 1,2-epoxides were characterized with respect to acute toxicity, cytotoxicity, analgesic activity, and influence on locomotion and exploration in an open-field test.
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页码：712 / 716
页数：4
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