Synthesis and Antimicrobial Activity of 3-Phenyl-1-Methylquinolin-2-One Derivatives

被引：0
|
作者：
O. V. Elenich
R. Z. Lytvyn
O. V. Blinder
O. V. Skripskaya
O. S. Lyavinets
Kh. E. Pitkovych
M. D. Obushak
P. I. Yagodinets
机构：
[1] Yuriy Fedkovych Chernivtsi National University,
[2] Ivan Franko National University of Lviv,undefined
[3] L. I. Medved Research Center of Preventive Toxicology,undefined
[4] Food and Chemical Safety,undefined
[5] Department of Medical and Environmental Problems,undefined
[6] Ministry of Health,undefined
来源：
Pharmaceutical Chemistry Journal | 2019年 / 52卷
关键词：
quinolin-2-one derivatives; synthesis; antimicrobial activity; quaternary salts; bromoketones; heterocyclization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of quaternary salts were obtained by reacting 3-(4-bromoacetylphenyl)-1-methylquinolin-2(1H)-one with Py, 4-methylpyridine, quinoline, benzo[f]quinoline, and triphenylphosphine. Derivatives of thiazole, imidazo[1,2-a]pyridine, and imidazo[1,2-a]pyrimidine were produced using dinucleophilic reagents. Several of the synthesized compounds possessed high antimicrobial activity, indicating that further research on this series of compounds was promising.
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页码：969 / 974
页数：5
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