Synthesis and calming activity of 2-amino-4-(4-β-d-allopyranoside-phenyl)-6-3(4)-substituted phenylpyrimidines

Using helicid as starting material, E-4-β-D-allopyranoside-cinnamic-4-substituted phenylketones (1a–1h) containing the structure of chalcones were synthesized; then these chalcones were reacted with guanidine hydrochloride through a 1,4-Michael reaction, giving 2-amino-4-(4-β-D-allopyranoside-phenyl)-6-3(4)substituted phenylpyrimidines (2a–2h), which were characterized by IR, 1H NMR, and HR-MS. The target compounds were evaluated by the spontaneous locomotor activity test, showing that all of them had good calming activity; compound 2f was found to have the greatest.