Synthesis and antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides

被引：0

作者：

Zimenkovskii B.S. ^{[1
]}

Kutsyk R.V. ^{[2
]}

Lesyk R.B. ^{[1
]}

Matyichuk V.S. ^{[3
]}

Obushak N.D. ^{[3
]}

Klyufinska T.I. ^{[2
]}

机构：

[1] Lviv National Medical University, Lviv

[2] Ivano-Frankivsk State Medical Academy, Ivano-Frankivsk

[3] Lviv National University, Lviv

来源：

Pharmaceutical Chemistry Journal | 2006年 / 40卷 / 6期

关键词：

Thiazole; Acetamide; Maleic Anhydride; Acid Amide; Thionyl Chloride;

D O I：

10.1007/s11094-006-0115-6

中图分类号：

学科分类号：

摘要：

The antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides and their 3-substituted analogs has been studied. The initial acid was obtained by an effective one-pot method using the reaction of thiourea with maleic anhydride in hydrochloric acid. The maximum anti-staphylococcal activity was exhibited by N-[5-(R-benzyl)thiazol-2-yl]-2-(2,4-dioxothiazolidin-5-yl) acetamides. © 2006 Springer Science+Business Media, Inc.

引用

页码：303 / 306

页数：3

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