Autism in Tuberous Sclerosis Complex

被引：0

作者：

Griselda C. Gutierrez

Susan L. Smalley

Peter E. Tanguay

机构：

[1] University of California,Department of Psychiatry

[2] University of California,Department of Psychiatry

[3] Los Angeles,undefined

[4] Neuropsychiatric Institute,undefined

[5] University of Louisville,undefined

来源：

Journal of Autism and Developmental Disorders | 1998年 / 28卷

关键词：

Tuberous sclerosis complex; autism; mental retardation; infantile spasms;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The frequency and clinical presentation of autism in 28 probands with tuberous sclerosis complex (TSC) are reported and risk factors that may influence the development of autism in TSC are examined. Eight probands meet ICD-10 and DSM-IV criteria for autism, an additional 4 meet criteria for pervasive developmental disorder (PDD). Twelve TSC probands with autism/PDD are compared to 16 TSC probands without these conditions for factors which may underlie the association of autism and TSC. A specific seizure type, infantile spasms, as well as mental retardation, are increased in the TSC, autistic/PDD group. Furthermore, rates of social phobia and substance abuse are elevated among first-degree relatives of TSC probands with autism compared to first-degree relatives of TSC probands without autism. Implications of these findings in understanding the association of autism and TSC are discussed.

引用

页码：97 / 103

页数：6

共 88 条

[1]

Abramson R. K.(1992)Biological liability in families with autism Journal of the American Academy of Child and Adolescent Psychiatry 31 370-371

[2]

Wright H. H.(1991)Therapeutic trial of vigabatrin in refractory infantile spasms Journal of Child Neurology 6 2852-2859

[3]

Cuccaro M. L.(1988)Correlation of family history with specific autistic sub-groups: Asperger's syndrome and bipolar affective disease Journal of Autism and Developmental Disorders 18 593-600

[4]

Lawrence L. G.(1993)Identification and characterization of the tuberous sclerosis gene on chromosome 16 Cell 75 1305-1315

[5]

Babb S.(1994)Autistic behavior and attention deficits in tuberous sclerosis: A population-based study Developmental Medicine and Child Neurology 36 50-56

[6]

Pencarinha D.(1994)Treatment of infantile spasms Annals of Pharmacotherapy 28 779-791

[7]

Marsteller F.(1987)Psychiatric disorder among children with tuberous sclerosis Developmental Medicine and Child Neurology 29 190-198

[8]

Harris E. C.(1993)A prevalence study of autism in tuberous sclerosis Journal of Autism and Developmental Disorders 23 323-340

[9]

Chiron C.(1992)Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease Nature Genetics 2 37-41

[10]

Dulac O.(1989)Autism diagnostic interview: A standardized investigator-based instrument Journal of Autism and Developmental Disorders 19 363-386

← 1 2 3 4 5 6 7 8 9 →