Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc

被引：0
作者：
Sarah K. Madden
Aline Dantas de Araujo
Mara Gerhardt
David P. Fairlie
Jody M. Mason
机构：
[1] University of Bath,Department of Biology & Biochemistry
[2] The University of Queensland,Division of Chemistry and Structural Biology and ARC 1066 Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience
来源：
Molecular Cancer | / 20卷
关键词：
Oncogene; Transcription; Leucine zipper; Peptide; Protein-protein interaction;
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摘要：
c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, suggesting this to be a viable therapeutic strategy. Here we reassess the challenges of directly targeting c-Myc, evaluate lessons learned from current inhibitors, and explore how future strategies such as miniaturisation of Omomyc and targeting E-box binding could facilitate translation of c-Myc inhibitors into the clinic.
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  • [1] Nair SK(2003)X-ray structures of Myc-Max and Mad-Max recognizing DNA: molecular bases of regulation by proto-oncogenictranscription factors Cell 112 193-205
  • [2] Burley SK(2015)Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis Biochim Biophys Acta 1849 484-500
  • [3] Diolaiti D(2001)The interplay between Mad and Myc in proliferation and differentiation Trends Cell Biol 11 S10-S14
  • [4] McFerrin L(2008)Reflecting on 25 years with MYC Nat Rev Cancer 8 976-990
  • [5] Carroll PA(2012)The Max b-HLH-LZ can transduce into cells and inhibit c-Myc transcriptional activities PLoS One 7 e32172-4054
  • [6] Eisenman RN(1988)Identification of the human c-myc protein nuclear translocation signal Mol Cell Biol 8 4048-7
  • [7] Zhou Z-Q(2017)Therapeutic interventions of cancers using intrinsically disordered proteins as drug targets: c-Myc as model system Cancer Informat 16 1-267
  • [8] Hurlin PJ(2019)Emerging roles of c-Myc in cancer stem cell-related signaling and resistance to cancer chemotherapy: a potential therapeutic target against colorectal cancer Int J Mol Sci 20 2340-75
  • [9] Meyer N(2020)Target gene-independent functions of MYC oncoproteins Nat Rev Mol Cell Biol 21 255-723.e714
  • [10] Penn LZ(2020)Targeting MYC proteins for tumor therapy Annu Rev Cancer Biol 4 61-776
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