Functionality of beta-adrenergic receptors in patients with cirrhosis treated chronically with non-selective beta-blockers

被引:0
作者
Susana Almenara
Beatriz Lozano
Paula Gimenez
Ivan Herrera
Cayetano Miralles
Pablo Bellot
María Rodríguez
Rubén Francés
Jose M. Gonzalez-Navajas
Sonia Pascual
Pedro Zapater
机构
[1] CIBERehd,Clinical Pharmacology Unit
[2] Instituto de Salud Carlos III,Instituto de Investigación, Desarrollo e Innovación en Biotecnologia Sanitaria de Elche, IDiBE
[3] Hospital General Universitario de Alicante,Clinical Medicine Department
[4] Universidad Miguel Hernández,Unidad de Farmacología Clínica
[5] Liver Unit,undefined
[6] Hospital General Universitario de Alicante,undefined
[7] Universidad Miguel Hernández,undefined
[8] Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL),undefined
[9] Hospital General Universitario de Alicante,undefined
来源
Hepatology International | 2020年 / 14卷
关键词
Portal hypertension; Beta-blockers; Beta-adrenoceptors; Peripheral blood mononuclear cells; cAMP; Catecholamines; Bacterial DNA; Endotoxin; Cytokines; Sympathetic nervous system;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:858 / 868
页数:10
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  • [1] Iwakiri Y(2006)The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule Hepatol Baltim Md 43 S121-131
  • [2] Groszmann RJ(1984)Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis Gut 25 1034-1043
  • [3] Henriksen JH(1991)Increased sympathetic outflow in cirrhosis and ascites: direct evidence from intraneural recordings Ann Intern Med 114 373-380
  • [4] Ring-Larsen H(1986)Alterations in isoprenaline sensitivity in patients with cirrhosis: evidence of abnormality of the sympathetic nervous activity Br J Clin Pharmacol 21 191-196
  • [5] Kanstrup IL(2006)Functional status of β-2-adrenoceptor in isolated membranes of mature erythrocytes from patients with cirrhosis and oesophageal varices Vascul Pharmacol 44 464-468
  • [6] Christensen NJ(2018)β2-adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: liver cirrhosis and osteoarthritis Mol Med Rep 17 7987-7995
  • [7] Floras JS(2002)Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites Hepatology 36 135-141
  • [8] Legault L(2004)Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites Gut 53 860-864
  • [9] Morali GA(2006)The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation Hepatology 44 633-639
  • [10] Hara K(2008)Presence of bacterial-DNA in cirrhosis identifies a subgroup of patients with marked inflammatory response not related to endotoxin J Hepatol 48 61-67