Dynamic changes of CSF sTREM2 in preclinical Alzheimer’s disease: the CABLE study

被引:0
作者
Ling-Zhi Ma
Lan Tan
Yan-Lin Bi
Xue-Ning Shen
Wei Xu
Ya-Hui Ma
Hong-Qi Li
Qiang Dong
Jin-Tai Yu
机构
[1] Qingdao University,Department of Neurology, Qingdao Municipal Hospital
[2] Qingdao University,Department of Anesthesiology, Qingdao Municipal Hospital
[3] Fudan University,Department of Neurology and Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College
来源
Molecular Neurodegeneration | / 15卷
关键词
Alzheimer’s disease; sTREM2; Inflammation; Biomarkers; Neurodegeneration;
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[1]  
Eikelenboom P(2011)The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer’s disease: neuropathological, epidemiological and genetic evidence Curr Alzheimer Res 8 142-150
[2]  
Veerhuis R(2015)Innate immunity in Alzheimer's disease Nat Immunol 16 229-236
[3]  
van Exel E(2013)The microglial sensome revealed by direct RNA sequencing Nat Neurosci 16 1896-1905
[4]  
Hoozemans JJ(2014)TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis Sci Transl Med 6 243ra86-207
[5]  
Rozemuller AJ(2016)TREM2 variants: new keys to decipher Alzheimer disease pathogenesis Nat Rev Neurosci 17 201-1568
[6]  
van Gool WA(2013)TREM2 and neurodegenerative disease N Engl J Med 369 1567-127
[7]  
Heneka MT(2013)TREM2 variants in Alzheimer's disease N Engl J Med 368 117-33036
[8]  
Golenbock DT(2013)Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and gamma-secretase-dependent intramembranous cleavage J Biol Chem 288 33027-3091
[9]  
Latz E(2008)Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation Brain 131 3081-933
[10]  
Hickman SE(2016)Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease Mol Neurodegener 11 3-476